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Merck
CN

61347

10,11-Dihydro-10-hydroxycarbamazepine

analytical standard

Synonym(s):

10,11-Dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide, Licarbazepine

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About This Item

Empirical Formula (Hill Notation):
C15H14N2O2
CAS Number:
29331-92-8
Molecular Weight:
254.28
UNSPSC Code:
41116107
PubChem Substance ID:
329759441
NACRES:
NA.24
Beilstein/REAXYS Number:
1540211
MDL number:
MFCD00871817

Key Documents

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SMILES string

N1(c2c(cccc2)C(Cc3c1cccc3)O)C(=O)N

InChI key

BMPDWHIDQYTSHX-UHFFFAOYSA-N

InChI

1S/C15H14N2O2/c16-15(19)17-12-7-3-1-5-10(12)9-14(18)11-6-2-4-8-13(11)17/h1-8,14,18H,9H2,(H2,16,19)

grade

analytical standard

assay

≥99% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Quality Level

100

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General description

10,11-Dihydro-10-hydroxycarbamazepine is an active metabolite of the antiepileptic drug, oxcarbazepine.
10,11-Dihydro-10-hydroxycarbamazepine is a 10-hydroxy derivative and an active metabolite of oxcarbazepine.

Application

10,11-Dihydro-10-hydroxycarbamazepine may be used as a reference standard in the determination of 10,11-dihydro-10-hydroxycarbamazepine in biological samples using liquid chromatography, liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) and high performance liquid chromatography coupled with ultraviolet detector (HPLC-UV).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

pictograms

Environment
GHS09

hcodes

H411

pcodes

P273

Hazard Classifications

Aquatic Chronic 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCK4194
BCCC9313
BCBT7305

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Juhyun Sim et al.
Forensic science international, 274, 91-98 (2017-01-24)
In recent years, the inappropriate use of antipsychotics by young Korean men has become a social problem. As military service exemptions are given for mental illness, some men pose as mental health patients to avoid military service. In order to
Depression and Bipolar Disorder: Stahl's Essential Psychopharmacology, 3rd Edition (2008)
Simultaneous high-performance liquid chromatography determination of carbamazepine and five of its metabolites in plasma of epileptic patients.
Mandrioli R, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 762(2), 109-116 (2001)
Shengyang Zhou et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1141, 122036-122036 (2020-02-29)
In this study, haptens were designed to produce highly sensitive and specific monoclonal antibodies (mAb) against carbamazepine (CBZ) and its metabolite carbamazepine-10, 11-epoxide (CBZ-EP). According to the results of our competitive enzyme-linked immunosorbent assay (ic-ELISA), the half-maximum inhibitory concentration values
First dose and steady-state pharmacokinetics of oxcarbazepine and its 10-hydroxy metabolite.
Dickinson R G, et al.
European Journal of Clinical Pharmacology, 37(1), 69-74 (1989)
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