61767
Lectin from Triticum vulgaris
lyophilized, ≥55% (GE), powder
Synonym(s):
WGA, Wheat germ agglutinin
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About This Item
Form:
powder
Biological source:
Triticum vulgaris
biological source
Triticum vulgaris
form
powder
quality
lyophilized
concentration
≥55% (GE)
technique(s)
agglutination assay: suitable using fresh human erythrocytes
storage temp.
2-8°C
General description
Lectins are carbohydrate-binding proteins, omnipresent, found in fungi, plants and animals. The structure of lectin is diversely studied in plants and animals. The secondary structure of this protein is rich in β-strands and posses a carbohydrate binding sites on the surface.
WGA is not blood group specific but has an affinity for N-acetyl-β-D-glucosaminyl residues and N-acetyl-β-D-glucosamine oligomers. WGA contains no protein-bound carbohydrate.
Application
Lectin from Triticum vulgaris has been used in bone resorption assays.
Wheat germ agglutinin conjugated to the outside surface of PLGA nanoparticles loaded with paclitaxel was used to target cancer cells that overexpress WGA-binding glycoproteins (Caco-2 and HT-29 cell lines). WGA-NP showed 50-60% greater endocytosis and intracellular retention of paclitaxel than unlabeled nanoparticles.
Biochem/physiol Actions
Lectin is known to be useful in glycoconjugate characterizing, imaging and targeting. Its use in a microarray assay, enable efficient glycome profiling. This is because of its specific interaction with oligosaccharides, glycoproteins and glycolipids. In plants and fungi, lectin defends against pathogens/feeders. Lectin participates in host recognition and tissue adhesion, thereby aids in the pathogenesis of microorganism.
Other Notes
Molecular characteristics and specificity for sugar binding
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
低风险生物材料
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Articles
Find the right lectin for your research with our lectin selection guide, organized by lectin source/species, carbohydrate specificity, blood group specificity, and more.
Yinglong Zhao et al.
Frontiers in cell and developmental biology, 9, 796902-796902 (2022-02-22)
Microgravity prominently affected cardiovascular health, which was the gravity-dependent physical factor. Deep space exploration had been increasing in frequency, but heart function was susceptible to conspicuous damage and cardiac mass declined in weightlessness. Understanding of the etiology of cardiac atrophy
Wheat germ agglutinin. Molecular characteristics and specificity for sugar binding.
Y Nagata et al.
The Journal of biological chemistry, 249(10), 3116-3122 (1974-05-25)
Alternative NF-kB Regulates RANKL-Induced Osteoclast Differentiation and Mitochondrial Biogenesis via Independent Mechanisms
Zeng R, et al.
Journal of Bone and Mineral Research, 30(12), 2287-2299 (2015)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 1533002-200MG | 04061838740755 |
| P6126-50G | 04061832092768 |
| P6126-25G | 04061834392958 |
| BP284 | 04061834419785 |
| Y0000683 | 04061837577673 |
| P8155-1VL | 04061834401070 |
| PHR1017-500MG | 04061835236916 |
| P6126-100G | 04061835253401 |
| P6126-10G | 04061834392941 |
| P-078-1ML | 04061834253907 |
| P1250000 | 04061834354277 |
| P6126-5G | 04061835253418 |
| 61767-5MG | 04061832700830 |