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63013

α2-Macroglobulin from human plasma

≥90% (GE)

Synonym(s):

α2-M

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About This Item

CAS Number:
1631137-21-7
UNSPSC Code:
12352202
NACRES:
NA.61
MDL number:
MFCD00130472
Assay:
≥90% (GE)
Biological source:
human plasma
Mol wt:
~720 kDa (four glycoprotein subunits)
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biological source

human plasma

Quality Segment

assay

≥90% (GE)

mol wt

~720 kDa (four glycoprotein subunits)

technique(s)

cell culture | mammalian: suitable

solubility

H2O: 1 mg/mL, clear to faintly turbid, colorless to faintly yellow

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... A2M(2)

Application

Inhibits all classes of endoproteases by forming a complex with the protease. When the protease cleaves the macroglobulin "bait" sequence, the macroglobulin rearranges and traps the protease.

Biochem/physiol Actions

α2-Macroglobulin is found abundantly in plasma and interstitial fluids. The protease-α2-M balance plays an important role in mediating inflammatory tissue destruction. Serum levels of α2-M and protease-α2-M complexes are increased in patients with sepsis, emphysema, periodontitis, rheumatoid arthritis, and other inflammatory diseases, and oxidant inactivation of α2-M may contribute to tissue destruction during inflammation.
Serum levels of α2-Macroglobulin (α2-M) and protease-α2-M complexes are increased in patients with sepsis, emphysema, periodontitis, rheumatoid arthritis and other inflammatory diseases. It is hypothesized that the oxidant inactivation of α2-M contributes to tissue destruction in inflammation.

Analysis Note

100 mg solids are lyophilized with 1 mg glycine from 35.2 mL 30 mM sodium phosphate, pH 7.0
Plasma from each donor has been tested and found negative for antibody to HIV-1/HIV-2, antibody to HCV and HbSAg.

Other Notes

Conformational changes of α2-M

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Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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