63013
α2-Macroglobulin from human plasma
≥90% (GE)
Synonym(s):
α2-M
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About This Item
Assay:
≥90% (GE)
Biological source:
human plasma
Mol wt:
~720 kDa (four glycoprotein subunits)
biological source
human plasma
Quality Segment
assay
≥90% (GE)
mol wt
~720 kDa (four glycoprotein subunits)
technique(s)
cell culture | mammalian: suitable
solubility
H2O: 1 mg/mL, clear to faintly turbid, colorless to faintly yellow
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... A2M(2)
Application
Inhibits all classes of endoproteases by forming a complex with the protease. When the protease cleaves the macroglobulin "bait" sequence, the macroglobulin rearranges and traps the protease.
Biochem/physiol Actions
α2-Macroglobulin is found abundantly in plasma and interstitial fluids. The protease-α2-M balance plays an important role in mediating inflammatory tissue destruction. Serum levels of α2-M and protease-α2-M complexes are increased in patients with sepsis, emphysema, periodontitis, rheumatoid arthritis, and other inflammatory diseases, and oxidant inactivation of α2-M may contribute to tissue destruction during inflammation.
Serum levels of α2-Macroglobulin (α2-M) and protease-α2-M complexes are increased in patients with sepsis, emphysema, periodontitis, rheumatoid arthritis and other inflammatory diseases. It is hypothesized that the oxidant inactivation of α2-M contributes to tissue destruction in inflammation.
Analysis Note
100 mg solids are lyophilized with 1 mg glycine from 35.2 mL 30 mM sodium phosphate, pH 7.0
Plasma from each donor has been tested and found negative for antibody to HIV-1/HIV-2, antibody to HCV and HbSAg.
Other Notes
Conformational changes of α2-M
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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