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D-Mannitol

Name: <SC>D</SC>-Mannitol
Brand: SIAL

ACS reagent, suitable for microbiology, ≥99.0%

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Synonym(s):

Mannite

Empirical Formula (Hill Notation):

C₆H₁₄O₆

CAS Number:

69-65-8

Molecular Weight:

182.17

Beilstein:

1721898

EC Number:

200-711-8

MDL number:

MFCD00064287

PubChem Substance ID:

329759874

NACRES:

NA.74

grade

ACS reagent

Quality Level

200

Assay

≥99.0% (sum of enantiomers, HPLC)
≥99.0%

form

powder

optical activity

[α]20/D +24.0±1° in borax solution acc. to ACS

ign. residue

≤0.01% (as SO₄)

loss

≤0.05% loss on drying, 20 °C (HV)

mp

165-169 °C
167-170 °C (lit.)

solubility

H₂O: 0.1 g/mL, clear, colorless

anion traces

chloride (Cl^-): ≤50 mg/kg
sulfate (SO₄^2-): ≤50 mg/kg

cation traces

As: ≤0.1 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg
heavy metals: ≤5 ppm (by ICP-OES)

application(s)

microbiology

SMILES string

OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO

InChI

1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1

InChI key

FBPFZTCFMRRESA-KVTDHHQDSA-N

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Microbial Culture Media Raw Materials

General description

D-Mannitol is a hexose present in plants, bacteria, algae, and fungi.

Application

D-Mannitol has been used as a component of soya flour mannitol (SFM) medium for culturing Streptomyces.

Biochem/physiol Actions

D-Mannitol finds application in the food and pharmaceutical industry. The interaction of mannitol with neutrophils and monocytes is correlated to the upregulation of immune markers. Mannitol acts as a free-radical scavenger and may be beneficial during ischemia-reperfusion injury. It possesses osmotic diuretic properties and may help in managing cerebral edema and high intracranial pressure (ICP).

A sugar alcohol sweet tastant. Used in sweetness inhibition studies.

Other Notes

Important starting material for the synthesis of many chiral building blocks.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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S. Hanessian

Total Synthesis of Natural Products: The Chiron Approach (1983)

Rapid Nitrate Reduction Assay with Intact Microbial Cells or Spores

Fischer M, et al.

Bio-protocol, 4(12) (4)

Mannitol upregulates monocyte HLA-DR, monocyte and neutrophil CD11b, and inhibits neutrophil apoptosis.

Matthias Turina et al.

Inflammation, 31(2), 74-83 (2007-10-25)

D-Mannitol is a substance widely used for both clinical applications as a strong diuretic and in basic research as a purportedly inert osmotic control substance. However, recent experiments have shown that mannitol is able to decrease neutrophil apoptosis in vitro

Y. Le Merrer et al.

Tetrahedron Letters, 26, 319-319 (1985)

Determination of Oxygen Respiration Rates in Wetted Developmentally Arrested Spores of Streptomyces Species