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Merck
CN

67403

Supelco

Cirsilineol

analytical standard

Synonym(s):

4′,5-Dihydroxy-3′,6,7-trimethoxyflavone, 6-Methoxyluteolin 3′,7-dimethyl ether, Anisomelin, Eupatrin, Fastigenin

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About This Item

Empirical Formula (Hill Notation):
C18H16O7
CAS Number:
41365-32-6
Molecular Weight:
344.32
Beilstein:
1355108
MDL number:
MFCD01083015
UNSPSC Code:
85151701
PubChem Substance ID:
329760578
NACRES:
NA.24

Key Documents

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grade

analytical standard

Quality Level

100

Assay

≥95.0% (HPLC and enzymatic)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

food and beverages

format

neat

SMILES string

COc1cc(ccc1O)C2=CC(=O)c3c(O)c(OC)c(OC)cc3O2

InChI

1S/C18H16O7/c1-22-13-6-9(4-5-10(13)19)12-7-11(20)16-14(25-12)8-15(23-2)18(24-3)17(16)21/h4-8,19,21H,1-3H3

InChI key

VKOSQMWSWLZQPA-UHFFFAOYSA-N

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General description

Cirsilineol is a bioactive flavone isolated from the herb of Artemisia vestita Wall., widely used to treat a variety of inflammatory conditions such as contact dermatitis, rheumatoid arthritis and sepsis. Cirsilineol exhibits anti-proliferative activity, which is used against different cancer cells by inducing apoptosis.

Application

Cirsilineol may be used as an analytical reference standard for the quantification of the analyte in vervain samples and extracts of Teucrium polium using chromatography techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCF8101
BCBZ9831
BCBZ6686
BCBV8675

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Cirsilineol inhibits proliferation of cancer cells by inducing apoptosis via mitochondrial pathway
Sheng X, et al.
The Journal of Pharmacy and Pharmacology, 60(11), 39-44 (2008)
Gjoshe Stefkov et al.
Pharmaceutical biology, 49(9), 885-892 (2011-05-31)
The main objective of the study was to investigate the biochemical mechanism of the antidiabetic activities of the dry extracts of Teucrium polium L. ssp. capitatum (L.) Arcangeli (Lamiaceae), from Republic of Macedonia, traditionally used to treat diabetes. Aerial parts
Qi-wei Zhang et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 27(1), 23-25 (2003-05-31)
To establish a quantitative method for determination of cirsilineol in Herba Artemisiae Scopariae collected in Autumn. Sample was extracted with methanol, and cleaned up with polyamide column. ODS column was used with methanol-acetonitrile-0.5% acetic acid solution (24:19:57) as mobile phase.
Yang Sun et al.
Biochemical pharmacology, 79(2), 229-238 (2009-08-25)
Regulation of signal transducer and activator of transcription (STAT) 1 signaling is being explored as a new approach to the treatment of inflammatory bowel diseases. However, few chemicals have been reported to inhibit IFN-gamma/STAT1 signaling for Crohn's disease therapy. In
[Flavones isolated from Thymus carnosus Boiss].
E Maruhenda et al.
Annales pharmaceutiques francaises, 45(6), 467-470 (1987-01-01)
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