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Merck
CN

67403

Cirsilineol

analytical standard

Synonym(s):

4′,5-Dihydroxy-3′,6,7-trimethoxyflavone, 6-Methoxyluteolin 3′,7-dimethyl ether, Anisomelin, Eupatrin, Fastigenin

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About This Item

Empirical Formula (Hill Notation):
C18H16O7
CAS Number:
41365-32-6
Molecular Weight:
344.32
UNSPSC Code:
85151701
NACRES:
NA.24
PubChem Substance ID:
329760578
MDL number:
MFCD01083015
Beilstein/REAXYS Number:
1355108

Key Documents

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InChI

1S/C18H16O7/c1-22-13-6-9(4-5-10(13)19)12-7-11(20)16-14(25-12)8-15(23-2)18(24-3)17(16)21/h4-8,19,21H,1-3H3

SMILES string

COc1cc(ccc1O)C2=CC(=O)c3c(O)c(OC)c(OC)cc3O2

InChI key

VKOSQMWSWLZQPA-UHFFFAOYSA-N

grade

analytical standard

assay

≥95.0% (HPLC and enzymatic)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

food and beverages

format

neat

Quality Level

100

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General description

Cirsilineol is a bioactive flavone isolated from the herb of Artemisia vestita Wall., widely used to treat a variety of inflammatory conditions such as contact dermatitis, rheumatoid arthritis and sepsis. Cirsilineol exhibits anti-proliferative activity, which is used against different cancer cells by inducing apoptosis.

Application

Cirsilineol may be used as an analytical reference standard for the quantification of the analyte in vervain samples and extracts of Teucrium polium using chromatography techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCF8101
BCBZ9831
BCBZ6686
BCBV8675

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Xia Sheng et al.
The Journal of pharmacy and pharmacology, 60(11), 1523-1529 (2008-10-30)
Cirsilineol (4',5-dihydroxy-3',6,7-trimethoxyflavone) is a compound isolated from the herb of Artemisia vestita Wall (Compositae). In this study, we aimed at examining the anti-proliferative activity of cirsilineol against multiple types of cancer cells and the underlying mechanisms. Cirsilineol significantly inhibited proliferation
[Flavones isolated from Thymus carnosus Boiss].
E Maruhenda et al.
Annales pharmaceutiques francaises, 45(6), 467-470 (1987-01-01)
HPLC and UV-spectrophotometry analysis of flavonoids in spray-dried and freez-dried extracts of Teucrium polium L.(Lamiaceae)
Stefkov G, et al.
Macedonian pharmaceutical bulletin, 47(11), 39-44 (2012)
Qi-wei Zhang et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 27(1), 23-25 (2003-05-31)
To establish a quantitative method for determination of cirsilineol in Herba Artemisiae Scopariae collected in Autumn. Sample was extracted with methanol, and cleaned up with polyamide column. ODS column was used with methanol-acetonitrile-0.5% acetic acid solution (24:19:57) as mobile phase.
Chun-nian He et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 30(10), 761-763 (2005-08-04)
To study the chemical constituents of Anoectochilus roxburghii. Silica gel and sephadex LH-20 column chromotography were used in the isolation from the ethanol extracts of the whole plant, the compounds were determined on the basis of various modern spectroscopic analysis
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