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69480

N-Methyl-N-trimethylsilylacetamide

Name: <I>N</I>-Methyl-<I>N</I>-trimethylsilylacetamide
Brand: SIAL

derivatization grade (GC derivatization), LiChropur^™, ≥97.0% (GC)

Synonym(s):

MSA

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About This Item

Empirical Formula (Hill Notation):

C₆H₁₅NOSi

CAS Number:

7449-74-3

Molecular Weight:

145.27

UNSPSC Code:

23151816

NACRES:

NA.22

PubChem Substance ID:

329761691

EC Number:

231-217-0

Beilstein/REAXYS Number:

506975

MDL number:

MFCD00040758

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grade

derivatization grade (GC derivatization)

Quality Level

100

assay

≥97.0% (GC)

form

liquid

quality

LiChropur^™

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

technique(s)

gas chromatography (GC): suitable

refractive index

n20/D 1.439

bp

159-161 °C (lit.)

density

0.904 g/mL at 20 °C (lit.)

storage temp.

−20°C

SMILES string

CN(C(C)=O)[Si](C)(C)C

InChI

1S/C6H15NOSi/c1-6(8)7(2)9(3,4)5/h1-5H3

InChI key

QHUOBLDKFGCVCG-UHFFFAOYSA-N

General description

N-Methyl-N-trimethylsilylacetamide is a trialkyl-silyl reagent and a versatile derivatizing agent used in gas chromatography (GC).

Application

N-Methyl-N-trimethylsilylacetamide may be used as a derivatizing reagent for the following:

Quantification of the carbohydrate intermediates in glycation systems using gas chromatography coupled to mass spectrometry technique.
Characterization of damaged products of thymine and cytosine formed by the exposure to UV light in a hydrogen peroxide solution using gas chromatography/mass spectrometry with scan mode and selected ion monitoring mode.

Other Notes

Powerful silylating agent for polar compounds

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

pictograms

GHS02

signalword

Warning

hcodes

H226

Hazard Classifications

Flam. Liq. 3

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

118.4 °F - closed cup

flash_point_c

48.0 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number

BCCB7757

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Public versus internal conceptions of addiction: An analysis of internal Philip Morris documents.

Jesse Elias et al.

PLoS medicine, 15(5), e1002562-e1002562 (2018-05-02)

Tobacco addiction is a complex, multicomponent phenomenon stemming from nicotine's pharmacology and the user's biology, psychology, sociology, and environment. After decades of public denial, the tobacco industry now agrees with public health authorities that nicotine is addictive. In 2000, Philip

Sample derivatization in separation science

Analytical separation science (2015)

J. Heberle et al.

Silylating Agents, 2nd ed. (1995)

M. Donike

Journal of Chromatography A, 103, 91-91 (1975)

Damaged products of thymine in hydroxyl radical solution under UV irradiation

Hong J, et al.

Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 63(1), 109-118 (1999)

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Results of a study involving the ability few Fluka silylating reagents to form GC-MS-compatible trimethylsilylmethyl derivatives of NSAIDs

Global Trade Item Number

SKU	GTIN
69480-10ML	04061832778969

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