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Merck
CN

69484

N-Methyl-N-trimethylsilylheptafluorobutyramide

derivatization grade (GC derivatization), LiChropur™, ≥90% (GC)

Synonym(s):

N-Trimethylsilyl-N-methylheptafluorobutyramide, MSHFBA

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About This Item

Linear Formula:
CF3CF2CF2CON(CH3)Si(CH3)3
CAS Number:
53296-64-3
Molecular Weight:
299.26
UNSPSC Code:
23151817
NACRES:
NA.22
PubChem Substance ID:
329761696
MDL number:
MFCD00077822
Beilstein/REAXYS Number:
6512894
Assay:
≥90% (GC)
Form:
liquid

Key Documents

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Product Name

N-Methyl-N-trimethylsilylheptafluorobutyramide, derivatization grade (GC derivatization), LiChropur™, ≥90% (GC)

InChI

1S/C8H12F7NOSi/c1-16(18(2,3)4)5(17)6(9,10)7(11,12)8(13,14)15/h1-4H3

SMILES string

CN(C(=O)C(F)(F)C(F)(F)C(F)(F)F)[Si](C)(C)C

InChI key

CMXKINNDZCNCEI-UHFFFAOYSA-N

grade

derivatization grade (GC derivatization)

assay

≥90% (GC)

form

liquid

quality

LiChropur™

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

technique(s)

gas chromatography (GC): suitable

refractive index

n20/D 1.353 (lit.)
n20/D 1.353

bp

148 °C (lit.)

density

1.254 g/mL at 25 °C (lit.)

Quality Level

100

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Application


  • Simultaneous quantitation of cocaine, opiates, and their metabolites in human hair by positive ion chemical ionization gas chromatography-mass spectrometry: This study demonstrates the application of N-Methyl-N-trimethylsilylheptafluorobutyramide in forensic toxicology to analyze drug residues in human hair, providing a robust method for detecting such compounds at trace levels (Höld KM, Wilkins DG, Rollins DE, Joseph RE Jr, Cone EJ, 1998).

  • Detection of stanozolol in hair by negative ion chemical ionization mass spectrometry: The research utilizes N-Methyl-N-trimethylsilylheptafluorobutyramide for the sensitive detection of stanozolol, a performance-enhancing steroid, in hair samples. This method is particularly useful in sports doping analyses to ensure fair play (Höld KM, Wilkins DG, Crouch DJ, Rollins DE, Maes RA, 1996).

Other Notes

N-methyl-N-trimethylsilylheptafluorobutyramide (MSHFBA) has been used in the silylation reaction during GC analysis of samples containing 1-monoolein, 2-monoolein, 1,2-diolein, 1,3-diolein, ethyl oleate, oleic acid and triolein.
Silylating agent for use in GC-analyses. It interferes least with flame-ionization detectors

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

91.4 °F - closed cup

flash_point_c

33 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Regulatory Information

危险化学品
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Certificates of Analysis (COA)

Lot/Batch Number
BCCN4321
BCCH3836
BCCC5184
BCBW8096
BCBS0963V

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Bing Fang et al.
Journal of food science and technology, 54(7), 1938-1944 (2017-07-20)
Tocopherols and sterols were lost considerably during the refining process of vegetable oils, resulting in a dramatic decrease in the oxidation stability. However, the oxidation stability of vegetable oils was not directly proportional to tocopherol content, not mention to its
Tobias Kieliba et al.
Drug testing and analysis, 11(2), 267-278 (2018-08-26)
The detection of Δ9 -tetrahydrocannabinol (THC), cannabidiol (CBD) and cannabinol (CBN) in hair, for the purpose of identifying cannabis consumption, is conducted in many forensic laboratories. Since external contamination of hair with these cannabis components cannot be excluded, even after
Joris Probst et al.
Experimental neurology, 331, 113330-113330 (2020-04-28)
Chronic hyperammonemia is a common condition affecting individuals with inherited urea cycle disorders resulting in progressive cognitive impairment and behavioral abnormalities. Altered neurotransmission has been proposed as major source of neuronal dysfunction during chronic hyperammonemia, but the molecular pathomechanism has
Effects of regioselectivity and lipid class specificity of lipases on transesterification, exemplified by biodiesel production.
Sinkuniene, Dovile, and Patrick Adlercreutz
Journal of the American Oil Chemists' Society, 97 (1), 1283-1290 (2014)
J. Heberle et al.
Silylating Agents, 2nd ed. (1995)
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