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Merck
CN

70127

Naloxone hydrochloride dihydrate

≥99.0% (TLC)

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About This Item

Empirical Formula (Hill Notation):
C19H21NO4 · HCl · 2H2O
CAS Number:
51481-60-8
Molecular Weight:
399.87
EC Number:
201-447-6
UNSPSC Code:
12352202
MDL number:
MFCD00150901
Beilstein/REAXYS Number:
6260807

Key Documents

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InChI

1S/C19H21NO4.ClH.2H2O/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11;;;/h2-4,14,17,21,23H,1,5-10H2;1H;2*1H2/t14-,17+,18+,19-;;;/m1.../s1

InChI key

TXMZWEASFRBVKY-IOQDSZRYSA-N

SMILES string

O.O.Cl.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O)CC=C

assay

≥99.0% (TLC)

storage temp.

2-8°C

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Application

Displaces morphine and other opiate agonists from the opiate receptor. In studies on the opiate receptor

Other Notes

Potent opiate antagonist.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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C Mollereau et al.
The Journal of biological chemistry, 263(34), 18003-18008 (1988-12-05)
When assayed for specific opiate binding in the presence of 120 mM NaCl, digitonin extracts from frog (Rana ridibunda) brain membranes were found to contain about the same quantity (0.5 pmol/mg of protein) of high (Kdh = 0.4 nM) and
T Costa et al.
Proceedings of the National Academy of Sciences of the United States of America, 86(19), 7321-7325 (1989-10-01)
According to classical models of drug-receptor interactions, competitive antagonists share with agonists the ability to bind to a common site on the receptor molecule. However, they are different from agonists, as they cannot trigger the "stimulus" that leads to biological
Yumei Liu et al.
PloS one, 8(1), e51573-e51573 (2013-02-06)
Previously, we demonstrated that electroacupuncture (EA) decreased lymphocyte infiltration into the spinal cords of rats presenting with experimental autoimmune encephalomyelitis (EAE), a disease model used in the study of multiple sclerosis (MS). The aim of this study was to characterize
Delia Aguado et al.
Anesthesiology, 118(5), 1160-1169 (2013-02-15)
Opioid antagonists at ultra-low doses have been used with opioid agonists to prevent or limit opioid tolerance. The aim of this study was to evaluate whether an ultra-low dose of naloxone combined with remifentanil could block opioid-induced hyperalgesia and tolerance
Opiate receptor antagonists for treatment of severe pruritus associated with advanced cholestatic liver disease.
Nilay Kumar et al.
Journal of palliative medicine, 16(2), 122-123 (2013-02-09)
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