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74147

Iohexol

analytical standard

Synonym(s):

5-[N-(2,3-Dihydroxypropyl)acetamido]-2,4,6-triiodo-N,N′-bis(2,3-dihydroxypropyl)isophthalamide

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About This Item

Empirical Formula (Hill Notation):
C19H26I3N3O9
CAS Number:
66108-95-0
Molecular Weight:
821.14
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329765500
EC Number:
266-164-2
Beilstein/REAXYS Number:
2406632
MDL number:
MFCD00077732
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grade

analytical standard

Quality Level

100

assay

≥95.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

impurities

≤6.0% water

application(s)

clinical testing

format

neat

SMILES string

IC1=C(C(NCC(O)CO)=O)C(I)=C(C(NCC(CO)O)=O)C(I)=C1N(CC(CO)O)C(C)=O

InChI

1S/C19H26I3N3O9/c1-8(29)25(4-11(32)7-28)17-15(21)12(18(33)23-2-9(30)5-26)14(20)13(16(17)22)19(34)24-3-10(31)6-27/h9-11,26-28,30-32H,2-7H2,1H3,(H,23,33)(H,24,34)

InChI key

NTHXOOBQLCIOLC-UHFFFAOYSA-N

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General description

Iohexol is a non-ionic, water-soluble contrast agent used as a reference marker to determine the glomerular filtration rate (GFR) which measures the level of kidney function. It finds applications in angiographic and urography procedures.

Application

Iohexol may be used as an internal standard for the determination of iohexol in human plasma, serum and urine samples by HPLC-UV method. It may also be used as a model compound to analyze the applicability of iohexol for glomerular filtration rate (GFR) measurement by the plasma clearance of iohexol in investigating renal failure.
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Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCP4428
BCCN0299
BCCK8829
BCCH0186
BCCC8343

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Performance of iohexol determination in serum and urine by HPLC: validation, risk and uncertainty assessment.
Cavalier E, et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 396(1-2), 80-85 (2008)
Human pharmacokinetics of iohexol. A new nonionic contrast medium.
BO, et al.
Investigative Radiology, 18(2), 177-182 (1983)
Development and validation of an HPLC-UV method for determination of iohexol in human plasma.
Soman R S, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 816(1-2), 339-343 (2005)
Iohexol clearance for GFR-determination in renal failure?single or multiple plasma sampling?.
Sterner G, et al.
Nephrology, Dialysis, and Transplantation, 11(3), 521-525 (1996)
Claire Francoz et al.
Hepatology (Baltimore, Md.), 59(4), 1514-1521 (2013-09-17)
Simultaneous liver and kidney transplantation (SLKT) remains the procedure of choice for patients with both endstage liver disease and kidney failure. Stringent guidelines are needed to avoid unnecessary kidney transplantation. A recent consensus meeting proposed criteria based on the Modified
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Global Trade Item Number

SKUGTIN
74147-50MG04061832884714

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