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85588

Spermine dihydrate

Name: Spermine dihydrate
Brand: SIAL

BioUltra, ≥99.5% (GC)

Synonym(s):

Gerontine, Musculamine, N,N′-Bis(3-aminopropyl)-1,4-diaminobutane, Neuridine

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About This Item

Linear Formula:

NH₂(CH₂)₃NH(CH₂)₄NH(CH₂)₃NH₂ · 2H₂O

CAS Number:

403982-64-9

Molecular Weight:

238.37

UNSPSC Code:

12352200

NACRES:

ND.02

PubChem Substance ID:

329769391

EC Number:

200-754-2

Beilstein/REAXYS Number:

7526933

MDL number:

MFCD01459904

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product line

BioUltra

Quality Level

100

assay

≥99.5% (GC)

form

powder

impurities

insoluble matter, passes filter test

pH

12.0-13.5 (25 °C, 1 M in H₂O)

mp

63-64 °C

solubility

H₂O: 1 M at 20 °C, clear, colorless

anion traces

chloride (Cl^-): ≤50 mg/kg, sulfate (SO₄^2-): ≤50 mg/kg

cation traces

Al: ≤5 mg/kg, As: ≤0.1 mg/kg, Ba: ≤5 mg/kg, Bi: ≤5 mg/kg, Ca: ≤10 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤5 mg/kg, K: ≤50 mg/kg, Li: ≤5 mg/kg, Mg: ≤5 mg/kg, Mn: ≤5 mg/kg, Mo: ≤5 mg/kg, Na: ≤50 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Sr: ≤5 mg/kg, Zn: ≤5 mg/kg

λ

1 M in H₂O

UV absorption

λ: 260 nm A_max: 0.20, λ: 280 nm A_max: 0.20

storage temp.

2-8°C

SMILES string

O.O.NCCCNCCCCNCCCN

InChI

1S/C10H26N4.2H2O/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;/h13-14H,1-12H2;2*1H2

InChI key

MTNRSMVAYLLBAV-UHFFFAOYSA-N

Related Categories

Biochemicals

Chemistry & Biochemicals

High-Purity Biochemicals and Reagents

Biochem/physiol Actions

Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Other Notes

Polyamines: Review; Inhibitor of ATPase; DNA polymerase; ribonuclease

pictograms

GHS05

signalword

Danger

hcodes

H314

pcodes

P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363

Hazard Classifications

Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number

BCCG7438

BCBR2118V

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Effect of polyamines on a ribonuclease which hydrolyzes ribonucleic acid at uridylic acid residues.

C C Levy et al.

The Journal of biological chemistry, 248(16), 5712-5719 (1973-08-25)

Specific effects of spermine on ouabain-sensitive and potassium-dependent phosphatase activity of kidney plasma membranes. Specificity of the potassium sites.

Y Tashima et al.

Biochimica et biophysica acta, 482(1), 1-10 (1977-05-12)

Specific inhibition of ouabain-sensitive and K+-dependent p-nitrophenyl-phosphatase activity of rabbit kidney plasma membranes by spermine (N,N'-bis(3-aminopropyl)-1,4-butanediamine) was characterized kinetically. 1. Inhibition by spermine was competitive with K+. The Ki for spermine was 31 micronM in the presence of 1 mM

Ca++ uptake in muscle microsomes. Activation by polyamines.

L De Meis

The Journal of biological chemistry, 243(6), 1174-1179 (1968-03-25)

Identification of SkpA-CulA-F-box E3 ligase complexes in pathogenic Aspergilli.

Dean Frawley et al.

Fungal genetics and biology : FG & B, 140, 103396-103396 (2020-04-24)

The ubiquitin proteasome system is critical for the regulation of protein turnover, which is implicated in the modulation of a wide array of biological processes in eukaryotes, ranging from cell senescence to virulence in plant and human hosts. Proteins to

A DNA polymerase from embryos of Drosophila melanogaster. Purification and properties.

J D Karkas et al.

The Journal of biological chemistry, 250(22), 8657-8663 (1975-11-25)

The more than 2,300-fold purification of a DNA polymerase from the embryos of Drosophila melanogaster is described. The enzyme, which forms a single band on gel electrophoresis, has a molecular weight of about 87,000 and a pH optimum of 8.5.

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Global Trade Item Number

SKU	GTIN
85588-5G	04061838055835
85588-25G	04061832938714

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