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Merck
CN

86018

Sulfacetamide

≥98.0% (NT)

Synonym(s):

N-(4-Aminobenzenesulfonyl)acetamide, N-(4-Aminophenylsulfonyl)acetamide, N1-Acetylsulfanilamide

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About This Item

Empirical Formula (Hill Notation):
C8H10N2O3S
CAS Number:
144-80-9
Molecular Weight:
214.24
EC Number:
205-640-6
UNSPSC Code:
51101500
PubChem Substance ID:
329769433
Beilstein/REAXYS Number:
981718
MDL number:
MFCD00066501

Key Documents

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assay

≥98.0% (NT)

ign. residue

≤0.4%

mp

182-184 °C

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, mycoplasma

mode of action

DNA synthesis | interferes

SMILES string

CC(=O)NS(=O)(=O)c1ccc(N)cc1

InChI

1S/C8H10N2O3S/c1-6(11)10-14(12,13)8-4-2-7(9)3-5-8/h2-5H,9H2,1H3,(H,10,11)

InChI key

SKIVFJLNDNKQPD-UHFFFAOYSA-N

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General description

Chemical structure: sulfonamide

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H317,H335

Hazard Classifications

Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 2

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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E Kremer et al.
Journal of inorganic biochemistry, 100(7), 1167-1175 (2006-04-06)
The synthesis, characterization and comparative biological study of a series of antibacterial copper complexes with heterocyclic sulfonamides were reported. Two kinds of complexes were obtained with the stoichiometries [Cu(L)2] . H2O and [Cu(L)2(H2O)4] . nH2O. They were characterized by infrared
Rade Injac et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 25(4), 424-431 (2008-03-19)
A separation technique for zinc bacitracin, polymyxin B, oxytetracycline and sulfacetamide in animal feedstuffs by micellar electrokinetic capillary chromatography (MEKC) was developed. The running buffer was 20 mmol l(-1) borate, 20 mmol l(-1) phosphate, pH 8.4, containing 20 mmol l(-1)
Meghan I Dubina et al.
Archives of dermatology, 145(9), 1027-1029 (2009-09-23)
A recent study demonstrated evidence of a yellow-orange discoloration of the skin and hair when topical dapsone gel was combined with benzoyl peroxide. This phenomenon had previously been observed by one of us (A.B.F.) when sulfasalazine was combined with benzoyl
Demet Sensoy et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 72(3), 487-495 (2009-02-19)
The aim of this study was to prepare bioadhesive sulfacetamide sodium (SA) microspheres to increase their residence time on the ocular surface and to enhance their treatment efficacy on ocular keratitis. Microspheres were fabricated by spray drying method using mixture
Mohamed L Elsaie et al.
Postgraduate medicine, 121(5), 178-186 (2009-10-13)
There are many options for the treatment of acne rosacea, including topical and systemic therapies, laser and light-based therapies, and surgical procedures. A classification system for rosacea identifies 4 subtypes (ie, erythematotelangiectatic, papulopustular, phymatous, and ocular), which may help guide
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