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Merck
CN

90834

Bradykinin acetate salt

analytical standard

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About This Item

Empirical Formula (Hill Notation):
C50H73N15O11 · xC2H4O2
CAS Number:
6846-03-3
Molecular Weight:
1060.21 (free base basis)
MDL number:
MFCD00076258
UNSPSC Code:
85151701
EC Number:
227-781-2
NACRES:
NA.24

Key Documents

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Product Name

Bradykinin acetate salt, analytical standard

SMILES string

N2([C@@H](CCC2)C(=O)NCC(=O)N[C@@H](Cc5ccccc5)C(=O)N[C@@H](CO)C(=O)N3[C@@H](CCC3)C(=O)N[C@@H](Cc4ccccc4)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCN=C(N)N

InChI key

QXZGBUJJYSLZLT-FDISYFBBSA-N

InChI

1S/C50H73N15O11/c51-32(16-7-21-56-49(52)53)45(72)65-25-11-20-39(65)47(74)64-24-9-18-37(64)43(70)58-28-40(67)59-34(26-30-12-3-1-4-13-30)41(68)62-36(29-66)46(73)63-23-10-19-38(63)44(71)61-35(27-31-14-5-2-6-15-31)42(69)60-33(48(75)76)17-8-22-57-50(54)55/h1-6,12-15,32-39,66H,7-11,16-29,51H2,(H,58,70)(H,59,67)(H,60,69)(H,61,71)(H,62,68)(H,75,76)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1

grade

analytical standard

assay

≥98.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

analyte chemical class(es)

peptides

technique(s)

HPLC: suitable

impurities

≤10 wt. % water

color

white

application(s)

food and beverages

format

neat

storage temp.

2-8°C

Quality Level

100

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Application

Bradykinin acetate salt may be used as a precursor for the preparation of bradykinin (BK) prior to its determination from acidic aqueous solutions by electromembrane extraction (EME) followed by analysis using high performance liquid chromatography (HPLC) with ultraviolet (UV) detector.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Activates pain receptors; induces smooth muscle contraction; activates Ca2+-dependent nitric oxide synthetase; increases capillary permeability.
Bradykinin is a pro-inflammatory peptide that acts through G-protein-coupled receptors. It activates sphingolipid metabolism. Fibroblasts treated with bradykinin produce a rapid and important increase in ceramide which is followed by a transient rise in sphingosine content. The peptide also increases ceramide cellular content by rapidly mobilizing neutral glycolipids. Bradykinin plays an important role in the regulation of fluid and electrolyte balance, smooth muscle contraction, vasodilation and capillary permeability. The bradykinin potentiators, which possess no bradykinin activity themselves, enhance the activity of bradykinin.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

涉药品监管产品
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Certificates of Analysis (COA)

Lot/Batch Number
BCCM2860
BCCK9706
BCCK3129
BCCJ8304
BCCG9835

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Electromembrane extraction of peptides-Fundamental studies on the supported liquid membrane.
Seip KF, et al.
Journal of Separation Science, 34(23), 3410-3417 (2011)

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