916641
2-(3-(Piperidin-4-yl)phenyl)ethan-1-amine dihydrochloride
95%
Synonym(s):
Semi-flexible linker for PROTAC® development
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About This Item
Empirical Formula (Hill Notation):
C13H22Cl2N2
Molecular Weight:
277.23
MDL number:
UNSPSC Code:
12352116
NACRES:
NA.22
Assay:
95%
Form:
powder
Quality Segment
assay
95%
form
powder
reaction suitability
reagent type: linker
functional group
amine
storage temp.
2-8°C
SMILES string
NCCC1=CC=CC(C2CCNCC2)=C1.Cl.Cl
InChI key
ZFXFMAUVGRWYEM-UHFFFAOYSA-N
Application
2-(3-(Piperidin-4-yl)phenyl)ethan-1-amine dihydrochloride is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.
Other Notes
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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