917869
2-(2-(Piperidin-4-yl)phenyl)acetic acid hydrochloride
≥95%
Synonym(s):
Semi-flexible linker for PROTAC® development
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About This Item
Empirical Formula (Hill Notation):
C13H18ClNO2
Molecular Weight:
255.74
UNSPSC Code:
12352106
Assay:
≥95%
Form:
powder and chunks
Product Name
2-(2-(Piperidin-4-yl)phenyl)acetic acid hydrochloride, ≥95%
SMILES string
O=C(CC1=C(C2CCNCC2)C=CC=C1)O.Cl
assay
≥95%
form
powder and chunks
reaction suitability
reagent type: linker
functional group
carboxylic acid
storage temp.
2-8°C
Quality Level
Application
2-(2-(Biperidin-4-yl)phenyl)acetic acid hydrochloride is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.
Other Notes
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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