Skip to Content
Merck
CN

92718

1-(Trimethylsilyl)imidazole - Pyridine mixture

derivatization grade (GC derivatization), LiChropur™

Synonym(s):

Silylating mixture VII, TMSI+Pyridine

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

CAS Number:
8077-35-8
UNSPSC Code:
23151816
eCl@ss:
39151701
PubChem Substance ID:
329770159
NACRES:
NA.22
MDL number:
MFCD00284770

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

1-(Trimethylsilyl)imidazole - Pyridine mixture, derivatization grade (GC derivatization), LiChropur™

SMILES string

c1ccncc1.C[Si](C)(C)n2ccnc2

InChI

1S/C6H12N2Si.C5H5N/c1-9(2,3)8-5-4-7-6-8;1-2-4-6-5-3-1/h4-6H,1-3H3;1-5H

InChI key

PFVKFOIOKNIZKY-UHFFFAOYSA-N

grade

derivatization grade (GC derivatization)

description

1:4 (v/v)

form

liquid

quality

LiChropur™

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

technique(s)

gas chromatography (GC): suitable

density

0.98 g/mL at 20 °C

storage temp.

2-8°C

Quality Level

100

Looking for similar products? Visit Product Comparison Guide

Related Categories

Application

Learn more in the Product Information

General description

1-(Trimethylsilyl)imidazole-Pyridine mixture is useful for derivatizing wet sugar samples, hindered hydroxyl groups in steroids and, in conjunction with fluorinated acylation reagents, amino acids. For moderately hindered or slowly reacting compounds, pyridine is an especially useful solvent for TMSI because of its ability to act as an HCl acceptor in silylation reactions involving organochlorosilanes.

Other Notes

Silylating mixture for the mild silylation of alcohols. It is often called Tri-Sil Z

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

62.6 °F - closed cup

flash_point_c

17 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Regulatory Information

危险化学品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
BCCL1007
BCCG6578
BCCC7877
BCCC3935
BCCB0533

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

G. Van Ling
Journal of Chromatography A, 44, 175-175 (1969)
M A Andrews
Carbohydrate research, 194, 1-19 (1989-12-01)
Two new procedures for the gas-chromatographic analysis of monosaccharides are reported. One involves derivatization of the sugars by reaction with O-benzylhydroxylamine followed by trifluoroacetylation with N-methylbis(trifluoroacetamide) and chromatography on a DB-1701 capillary column. This technique probably provides the best resolution

Articles

Silylation of Non-Steroidal Anti-Inflammatory Drugs

Results of a study involving the ability few Fluka silylating reagents to form GC-MS-compatible trimethylsilylmethyl derivatives of NSAIDs

Related Content

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service