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Merck
CN

92817

9-Aminoacridine

suitable for matrix substance for MALDI-MS, ≥99.5% (HPLC)

Synonym(s):

Aminacrine

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About This Item

Empirical Formula (Hill Notation):
C13H10N2
CAS Number:
Molecular Weight:
194.23
NACRES:
NA.21
PubChem Substance ID:
UNSPSC Code:
23151816
EC Number:
201-995-6
MDL number:
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Product Name

9-Aminoacridine, suitable for matrix substance for MALDI-MS, ≥99.5% (HPLC)

InChI key

XJGFWWJLMVZSIG-UHFFFAOYSA-N

InChI

1S/C13H10N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1-8H,(H2,14,15)

SMILES string

Nc1c2ccccc2nc3ccccc13

assay

≥99.5% (HPLC)

form

powder

analyte functional class(es)

metabolites

analyte chemical class(es)

lipids

technique(s)

MALDI-MS: suitable

impurities

≤0.05% sulfated ash

loss

≤10% loss on drying

mp

238-240 °C

cation traces

Ba: ≤5 mg/kg
Ca: ≤200 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Fe: ≤10 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg
K: ≤100 mg/kg
Na: ≤100 mg/kg

suitability

suitable for matrix substance for MALDI-MS

Quality Level

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Application

A MALDI matrix exhibiting low background and good sensitivity in the analysis of low molecular weight anions, such as metabolites, in negative mode

General description

9-Aminoacridine, an aminoacridine dye which acts as a potent mutagen in viruses and bacteria.

pictograms

Exclamation markEnvironment

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Moumita Paul et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 16(5), 735-743 (2011-04-06)
In this study, the detailed DNA sequence specificity of four acridine Pt complexes was examined and compared with that of cisplatin. The DNA sequence specificity was determined in a telomere-containing DNA sequence using a polymerase stop assay, with a fluorescent
Masahiro Kawashima et al.
British journal of cancer, 122(2), 245-257 (2019-12-11)
The fatty acid (FA) composition of phosphatidylinositols (PIs) is tightly regulated in mammalian tissue since its disruption impairs normal cellular functions. We previously found its significant alteration in breast cancer by using matrix-assisted laser desorption and ionisation imaging mass spectrometry
John Marshall et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 27(8), 1495-1506 (2019-06-19)
Neuronopathic glycosphingolipidoses are a sub-group of lysosomal storage disorders for which there are presently no effective therapies. Here, we evaluated the potential of substrate reduction therapy (SRT) using an inhibitor of glucosylceramide synthase (GCS) to decrease the synthesis of glucosylceramide
Pawel L Urban et al.
Analytical chemistry, 83(10), 3918-3925 (2011-04-28)
Fruit fly (Drosophila melanogaster) is a standard model organism used in genetics and molecular biology. Phospholipids are building blocks of cellular membranes, and components of a complex signaling network. Here, we present a facile method, based on matrix-assisted laser desorption/ionization
Yusuke Muranishi et al.
Scientific reports, 9(1), 8916-8916 (2019-06-22)
Adenocarcinoma is the most common type of lung cancer, and can be classified into various histologic subtypes. However, little is known about the subtype-dependent variations in lipid metabolism processes. We performed dual lipidomic analyses using liquid chromatography-mass spectrometry (LC-MS) and

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