92822
Picrylsulfonic acid solution
1 M in H2O
Synonym(s):
2,4,6-Trinitrobenzenesulfonic acid solution, TNBS
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About This Item
Empirical Formula (Hill Notation):
C6H3N3O9S
CAS Number:
Molecular Weight:
293.17
UNSPSC Code:
12352005
NACRES:
NA.25
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
572358
Concentration:
1 M in H2O
Form:
liquid
form
liquid
Quality Level
concentration
1 M in H2O
solubility
water: soluble at 20 °C
density
1.14 g/mL at 20 °C
ε (extinction coefficient)
≤0.85 at 340 nm
shipped in
dry ice
storage temp.
−20°C
SMILES string
OS(=O)(=O)c1c(cc(cc1[N+]([O-])=O)[N+]([O-])=O)[N+]([O-])=O
InChI
1S/C6H3N3O9S/c10-7(11)3-1-4(8(12)13)6(19(16,17)18)5(2-3)9(14)15/h1-2H,(H,16,17,18)
InChI key
NHJVRSWLHSJWIN-UHFFFAOYSA-N
Application
Hydrophilic modifying reagent. Derivatives with amino compounds can be regenerated with hydrazine.
Picrylsulfonic acid (2,4,6-Trinitrobenzenesulfonic acid solution, TNBS) may be used in studies on the mechanisms of intracellular pH regulation. TNBS is used to induce inflammatory bowel disease (IBD)/colonic inflammation for studies on its mechanism and treatment.
Other Notes
Sales restrictions may apply
Disclaimer
decomposes when stored at temperatures ≥0°C with precipitate formation (picric acid)
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Desen. Expl. 3 - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1
Storage Class
3 - Flammable liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Regulatory Information
监管及禁止进口产品
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A Arranz et al.
Journal of controlled release : official journal of the Controlled Release Society, 165(3), 163-172 (2012-11-28)
CD40-CD40L interactions appear to play an important role in the pathogenesis of experimental colitis. We tested the effect and investigated the underlying mechanism of action of systemically administered antisense oligonucleotide (ASO) targeting CD40 formulated in amphoteric liposomes (nov038/CD40). The charge
Carla Petrella et al.
Pharmacological research, 70(1), 72-79 (2013-01-29)
Nociceptin/orphanin FQ (N/OFQ) and nociceptin orphanin peptide (NOP) receptors represent an endogenous system modulating gastrointestinal functions and inflammation. We investigated the peripheral effect of N/OFQ and of UFP-101, the NOP antagonist, in a model of colitis induced by TNBS (2,4,6
Zhen Huang et al.
Gut, 63(8), 1247-1257 (2013-09-04)
Emerging evidence suggests that microRNA (miRNA)-mediated gene regulation influences a variety of autoimmune disease processes, including Crohn's disease (CD), but the biological function of miRNAs in CD remains unclear. We examine miRNA level in colon tissues and study the potential
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 92822-5ML | 04061837839443 |
| 92822-10ML | 04061837839412 |
| 92822-50ML | 04061837839436 |
| 92822-1ML | 04061837839429 |