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About This Item
Linear Formula:
H2N(CH2)5CO2H
CAS Number:
Molecular Weight:
131.17
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
906872
Product Name
Aminocaproic acid, European Pharmacopoeia (EP) Reference Standard
InChI
1S/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9)
SMILES string
NCCCCCC(O)=O
InChI key
SLXKOJJOQWFEFD-UHFFFAOYSA-N
grade
pharmaceutical primary standard
API family
aminocaproic acid
manufacturer/tradename
EDQM
mp
207-209 °C (dec.) (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
Gene Information
human ... PLAT(5327), PLG(5340)
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Application
Aminocaproic acid EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
Biochem/physiol Actions
Lysine analog. Promotes rapid dissociation of plasmin, thereby inhibiting the activation of plasminogen and subsequent fibrinolysis.
Lysine analog. Promotes rapid dissociation of plasmin, thereby inhibiting the activation of plasminogen and subsequent fibrinolysis. Reported to inhibit plasminogen binding to activated platelets. An early report indicated that it inhibits the activation of the first component of the complement system. Binds and inactivates Carboxypeptidase B.
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Other Notes
Sales restrictions may apply.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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G Manjunath et al.
Clinical nephrology, 58(1), 63-67 (2002-07-27)
Epsilon-aminocaproic acid (EACA) is a potent anti-fibrinolytic agent that is used in the treatment of excessive bleeding resulting from a systemic fibrinolytic state. It can also be used to treat hematuria through its action on decreasing urinary fibrinolysis. A broad
Allergic contact dermatitis due to epsilon-aminocaproic acid: a case report and mini-review of the published work.
Yuriko Yamamoto et al.
The Journal of dermatology, 40(4), 301-303 (2013-02-13)
O N Lucas et al.
Oral surgery, oral medicine, and oral pathology, 51(2), 115-120 (1981-02-01)
On the basis of our review of the literature, it can be concluded that the advantages of E-A.C.A. include (1) safe execution of oral surgical procedures in persons with hemophilia of varying degrees of severity, (2) decrease or total elimination
Are antifibrinolytic agents effective in the treatment of aneurysmal subarachnoid hemorrhage?
Travis R Eastin et al.
Annals of emergency medicine, 64(6), 658-659 (2014-06-24)
Blood-sparing drugs: aprotinin, tranexamic acid, and epsilon-aminocaproic acid.
D Royston
International anesthesiology clinics, 33(1), 155-179 (1995-01-01)
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