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Merck
CN

B2635

Busulfan

analytical standard, for drug analysis

Synonym(s):

1,4-Butanediol dimethanesulfonate

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About This Item

Linear Formula:
CH3SO2O(CH2)4OSO2CH3
CAS Number:
55-98-1
Molecular Weight:
246.30
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329773205
EC Number:
200-250-2
Beilstein/REAXYS Number:
1791786
MDL number:
MFCD00007562

Key Documents

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InChI key

COVZYZSDYWQREU-UHFFFAOYSA-N

InChI

1S/C6H14O6S2/c1-13(7,8)11-5-3-4-6-12-14(2,9)10/h3-6H2,1-2H3

SMILES string

CS(=O)(=O)OCCCCOS(C)(=O)=O

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

114-117 °C (lit.)

application(s)

forensics and toxicology
veterinary

format

neat

Quality Level

100

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General description

Busulfan is a bifunctional alkylating agent, which may find application in the treatment of chronic granulocytic leukemia.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Carc. 1A - Muta. 1B - Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
WXBF5371V
WXBF3873V
BCCK8828
BCCG5556
BCCF4469

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Blood and Marrow Stem Cell Transplantation: Principles, Practice, and Nursing Insights (1997)
Christopher Bredeson et al.
Blood, 122(24), 3871-3878 (2013-10-02)
We conducted a prospective cohort study testing the noninferiority of survival of ablative intravenous busulfan (IV-BU) vs ablative total body irradiation (TBI)-based regimens in myeloid malignancies. A total of 1483 patients undergoing transplantation for myeloid malignancies (IV-BU, N = 1025;
Manabu Ozawa et al.
Biology of reproduction, 94(4), 92-92 (2016-03-18)
The F-box and leucine-rich repeat protein 10 (Fbxl10) gene encodes a protein that catalyzes demethylation of H3K4 and H3K36. In this study, we show the important roles of FBXL10 as a histone demethylase in sustainable sperm production using mice in
Naira Caroline Godoy Pieri et al.
Stem cell research & therapy, 10(1), 135-135 (2019-05-22)
Xenotransplantation of spermatogonial stem cells (SSCs) has become a popular topic in various research fields because manipulating these cells can provide insights into the mechanisms associated with germ cell lines and the entire spermatogenesis process; moreover, these cells can be
M Hassan et al.
Leukemia & lymphoma, 22(5-6), 395-407 (1996-08-01)
Busulfan as a high-dose therapy is an important component of many of the myeloablative regimens for both allogeneic and autologous bone marrow transplantation (BMT) in adults and children. During the last decade, several studies have shown a wide inter- and
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