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B3420

Sodium benzoate

Name: Sodium benzoate
Brand: SIAL

BioXtra, ≥99.5%

Synonym(s):

Benzoic acid sodium salt

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About This Item

Linear Formula:

C₆H₅COONa

CAS Number:

532-32-1

Molecular Weight:

144.10

NACRES:

NA.25

PubChem Substance ID:

24891719

eCl@ss:

39024301

UNSPSC Code:

12352107

EC Number:

208-534-8

MDL number:

MFCD00012463

Beilstein/REAXYS Number:

3572467

Assay:

≥99.5%

Form:

powder

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product line

BioXtra

Quality Level

200

assay

≥99.5%

form

powder

impurities

≤0.0005% Phosphorus (P), ≤0.1% Insoluble matter

mp

>300 °C (lit.)

solubility

H₂O: 1 M, clear, colorless

anion traces

chloride (Cl^-): ≤0.05%, sulfate (SO₄^2-): ≤0.05%

cation traces

Al: ≤0.0005%, Ca: ≤0.01%, Cu: ≤0.0005%, Fe: ≤0.0005%, K: ≤0.10%, Mg: ≤0.005%, NH₄⁺: ≤0.05%, Pb: ≤0.001%, Zn: ≤0.0005%

SMILES string

[Na+].[O-]C(=O)c1ccccc1

InChI

1S/C7H6O2.Na/c8-7(9)6-4-2-1-3-5-6;/h1-5H,(H,8,9);/q;+1/p-1

InChI key

WXMKPNITSTVMEF-UHFFFAOYSA-M

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Biochemicals

High-Purity Biochemicals and Reagents

General description

Sodium benzoate is a safe food preservative and has antimicrobial functionality. It has a molecular weight of 114.11 Da. Sodium benzoate is used in bakery products, juice and cheese. In the liver, it is conjugated to glycine and is eliminated as hippuric acid from the urine.

Application

Sodium benzoate has been used to test its effect on phencyclidine (PCP) induced locomotor activity in mice.

Biochem/physiol Actions

Sodium benzoate also has pharmaceutical applications and is component of syrup and transparent tablet. High levels of sodium benzoate may trigger histamine release and also induce cell damage. It is recommended for the treatment of urea cycle disorders. However, high levels of sodium benzoate may contribute to glycine deficiency and may impose neuromodulatory effects.

Disclaimer

The product is not intended for use as a biocide under global biocide regulations, including but not limited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, European Biocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’s Biocidal Products Regulation, Korea’s Consumer Chemical Products and Biocide Safety Management Act (K-BPR) and others.

pictograms

GHS07

signalword

Warning

hcodes

H319

pcodes

P264 - P280 - P305 + P351 + P338 - P337 + P313

Hazard Classifications

Eye Irrit. 2

Storage Class

13 - Non Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Benzoate and sorbate salts: a systematic review of the potential hazards of these invaluable preservatives and the expanding spectrum of clinical uses for sodium benzoate

Piper JD and Piper PW

Comprehensive Reviews in Food Science and Food Safety, 16(5), 868-880 (2017)

Modulating NMDA receptor function with D-amino acid oxidase inhibitors: understanding functional activity in PCP-treated mouse model

Sershen H, et al.

Neurochemical Research, 41(1-2), 398-408 (2016)

An Overview on the Effects of Sodium Benzoate as a Preservative in Food Products

Shahmohammadi M, et al.

Biotechnology and Health Sciences, 3(3), 7-11 (2016)

Weak Acid Permeation in Synthetic Lipid Vesicles and Across the Yeast Plasma Membrane.

Matteo Gabba et al.

Biophysical journal, 118(2), 422-434 (2019-12-18)

We present a fluorescence-based approach for determination of the permeability of small molecules across the membranes of lipid vesicles and living cells. With properly designed experiments, the method allows us to assess the membrane physical properties both in vitro and in vivo.

Sodium benzoate, a metabolite of cinnamon and a food additive, upregulates neuroprotective Parkinson disease protein DJ-1 in astrocytes and neurons.

Saurabh Khasnavis et al.

Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 7(2), 424-435 (2011-06-28)

DJ-1 (PARK7) is a neuroprotective protein that protects cells from oxidative stress. Accordingly, loss-of-function DJ-1 mutations have been linked with a familial form of early onset Parkinson disease. Mechanisms by which DJ-1 level could be enriched in the CNS are

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Global Trade Item Number

SKU	GTIN
B3420-1KG	04061833427880
B3420-250G	04061835542840

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