B5899
Buflomedil hydrochloride
analytical standard
Synonym(s):
4-(1-Pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone
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About This Item
Empirical Formula (Hill Notation):
C17H25NO4 · HCl
CAS Number:
Molecular Weight:
343.85
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
252-611-9
MDL number:
grade
analytical standard
Quality Segment
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
veterinary
format
neat
SMILES string
Cl.COc1cc(OC)c(C(=O)CCCN2CCCC2)c(OC)c1
InChI
1S/C17H25NO4.ClH/c1-20-13-11-15(21-2)17(16(12-13)22-3)14(19)7-6-10-18-8-4-5-9-18;/h11-12H,4-10H2,1-3H3;1H
InChI key
ZDPACSAHMZADFZ-UHFFFAOYSA-N
Gene Information
human ... EBP(10682)
General description
Buflomedil hydrochloride is a vasoactive agent. Its mode of action involves increasing the peripheral and cerebral blood flow in ischaemic tissues of patients, who are mostly affected with vascular diseases.
Application
Buflomedil hydrochloride may be used as an analytical standard for the determination of buflomedil in biological matrices using high-performance liquid chromatography technique. It may also be used as an analytical reference standard for the quantification of the analyte in pharmaceutical formulations and serum samples using electroanalytical and chromatographic techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Quantification of the Vasoactive Agent Buflomedil HCl in Pharmaceutical Formulation and Human Serum by Stripping Voltammetry and Liquid Chromatography
El-Desoky.SH, et al.
Acta Chimica Slovenica, 57(2), 18-21 (2010)
Claudio Bucolo et al.
Pharmacoepidemiology and drug safety, 21(11), 1190-1196 (2012-08-03)
Review all the individualized cases of adverse drug reaction (ADR) potentially related to buflomedil, a vasodilator with the indication for peripheral arterial disease (PAD), marketed in Europe since the 1970s but recently suspended by the European Medicines Agency. A review
Buflomedil: still too many fatal cardiac and neurological events.
Prescrire international, 20(115), 99-99 (2011-06-09)