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Merck
CN

B7536

Buprenorphine hydrochloride solution

analytical standard, for drug analysis

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About This Item

Empirical Formula (Hill Notation):
C29H41NO4 · HCl
CAS Number:
53152-21-9
Molecular Weight:
504.10
NACRES:
NA.24
PubChem Substance ID:
329773297
UNSPSC Code:
41116107
EC Number:
200-659-6
MDL number:
MFCD00084836

Key Documents

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InChI key

UAIXRPCCYXNJMQ-RZIPZOSSSA-N

InChI

1S/C29H41NO4.ClH/c1-25(2,3)26(4,32)20-15-27-10-11-29(20,33-5)24-28(27)12-13-30(16-17-6-7-17)21(27)14-18-8-9-19(31)23(34-24)22(18)28;/h8-9,17,20-21,24,31-32H,6-7,10-16H2,1-5H3;1H/t20-,21-,24-,26+,27-,28+,29-;/m1./s1

SMILES string

Cl.CO[C@]12CC[C@@]3(CC1[C@](C)(O)C(C)(C)C)[C@H]4Cc5ccc(O)c6OC2[C@]3(CCN4CC7CC7)c56

Quality Level

200

drug control

Home Office Schedule 3; psychotrope (France); kontrollierte Droge in Deutschland; (Spain); Decreto Lei 15/93: Tabela IIC (Portugal); Pszichotróp anyag / Psychotropic Substance (Hungary), 78/2022. (XII. 28.) BM rendelet, kontrollierte Droge in Deutschland

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

single component solution

storage temp.

−20°C

Related Categories

Application

Buprenorphine hydrochloride solution may be used as a reference standard in the determination of buprenorphine in samples of human plasma using gas chromatography coupled with mass spectrometry (GC/MS).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.

English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes

Storage Class

3 - Flammable liquids

wgk

WGK 2

flash_point_f

51.8 °F - closed cup

flash_point_c

11 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves

Regulatory Information

监管及禁止进口产品
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Certificates of Analysis (COA)

Lot/Batch Number
0000320393
0000320393
0000276671
0000249856
0000276671

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Bilin Liu et al.
STAR protocols, 1(3), 100186-100186 (2020-12-31)
Here, we present a modified protocol for a mouse heart failure (HF) model using minimally invasive transverse aortic constriction (miTAC). miTAC is a more effective method in mice than the standard open-chest transverse aortic constriction (TAC) to generate an HF
Development and validation of a sensitive analytical method for the simultaneous determination of buprenorphine and norbuprenorphine in human plasma.
Gopal S, et al.
European Journal of Pharmaceutics and Biopharmaceutics, 51(2), 147-151 (2001)
Afarin Rahimi-Movaghar et al.
The Cochrane database of systematic reviews, 1(1), CD007775-CD007775 (2013-02-27)
Pharmacologic therapies for maintenance treatment of heroin dependence have been used and studied widely. Systematic reviews have demonstrated the effectiveness of such therapies. Opium dependence is associated with less problems and impairments and is less likely to be used by
Huei-Ru Lin et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 925, 10-15 (2013-03-20)
For monitoring compliance of methadone or buprenorphine maintenance patient, a method for the simultaneous determination of methadone, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP), buprenorphine, norbuprenorphine, opiates (morphine, codeine, 6-monoacetylmorphine) in urine by superficially porous liquid chromatography tandem mass spectrometry was developed and validated. After
K Wahle et al.
MMW Fortschritte der Medizin, 155 Suppl 1, 25-31 (2013-05-18)
Chronic pain in the elderly is common. Especially in the elderly inadequate treatment of pain can cause significant functional impairmentand deterioration of qualityof life. Theaim of this post-marketing surveillance study was to collect data from clinical practice on the analgesic
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