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BP460

Nicotinamide

British Pharmacopoeia (BP) Reference Standard

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Synonym(s):
NAM, NIC, Niacinamide, Nicotinic acid amide, Pyridine-3-carboxylic acid amide, Vitamin B3, Vitamin PP
Empirical Formula (Hill Notation):
C6H6N2O
CAS Number:
98-92-0
Molecular Weight:
122.12
Beilstein:
383619
MDL number:
MFCD00006395
NACRES:
NA.24

grade

pharmaceutical primary standard

Agency

BP

API family

nicotinamide

form

solid

manufacturer/tradename

BP

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

mp

128-131 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

−20°C

SMILES string

NC(=O)c1cccnc1

InChI

1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)

InChI key

DFPAKSUCGFBDDF-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Nicotinamide, a member of the family of water-soluble B vitamins, is generally produced from nicotinic acid (vitamin B3). It is often present in food products. It has been reported to have been effective in the treatment of pellagra, psoriasis, schizophrenia, and type I diabetes. It is also shown to possess anti-inflammatory activity.

Biochem/physiol Actions

Nicotinamide is an amide derivative of vitamin B3 and a PARP inhibitor

Packaging

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

Other Notes

Sales restrictions may apply.

related product

Product No.
Description
Pricing

N0600000

Nicotinamide, European Pharmacopoeia (EP) Reference Standard

PHR1033

Niacinamide, Pharmaceutical Secondary Standard; Certified Reference Material

1462006

Niacinamide, United States Pharmacopeia (USP) Reference Standard

E2400000

Ethylnicotinamide, European Pharmacopoeia (EP) Reference Standard

BP1104

N-(2-Hydroxyethyl)isonicotinamide nitric ester, British Pharmacopoeia (BP) Reference Standard

PHR2089

Nicotinamide Impurity D, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2090

Nicotinamide Impurity E, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2088

Nicotinamide Impurity C, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2087

Nicotinamide Impurity B, Pharmaceutical Secondary Standard; Certified Reference Material

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H319

Hazard Classifications

Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

302.0 °F - closed cup

Flash Point(C)

150 °C - closed cup

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Evaluation of analytical tools and multivariate methods for quantification of co-former crystals in ibuprofen-nicotinamide co-crystals
Soares FLF and Carneiro RL
Journal of Pharmaceutical and Biomedical Analysis, 89, 166-175 (2014)
Nicotinamide
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 14(4), 3145-3146 (2017)
Development of a validated HPLC method for the determination of B-complex vitamins in pharmaceuticals and biological fluids after solid phase extraction
Chatzimichalakis PF, et al.
Journal of Separation Science, 27(14), 1181-1188 (2004)
Simultaneous determination and classification of riboflavin, thiamine, nicotinamide and pyridoxine in pharmaceutical formulations, by UV-visible spectrophotometry and multivariate analysis
Lopez-de-Alba LP, et al.
Journal of the Brazilian Chemical Society, 17(4), 715-722 (2006)
Youdan Shi et al.
International immunopharmacology, 14(4), 530-537 (2012-10-13)
Nicotinamide (NAM), the amide form of vitamin B3, is involved in a wide range of biological processes. Recent evidence revealed the anti-inflammatory and anti-oxidant properties of NAM and suggests it may be used as a novel strategy in the prevention

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