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BP489

Fluocinonide

British Pharmacopoeia (BP) Reference Standard

Synonym(s):

(6α,11β,16α)-21-(acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-pregna-1,4-diene-3,20-dione, Lonide

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About This Item

Empirical Formula (Hill Notation):
C26H32F2O7
CAS Number:
356-12-7
Molecular Weight:
494.52
UNSPSC Code:
41116107
NACRES:
NA.24
MDL number:
MFCD00079302
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grade

pharmaceutical primary standard

API family

fluocinonide

form

solid

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

BP

application(s)

pharmaceutical
pharmaceutical small molecule

format

neat

storage temp.

2-8°C

SMILES string

CC(=O)OCC(=O)[C@@]12OC(C)(C)O[C@@H]1C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]23C

InChI

1S/C26H32F2O7/c1-13(29)33-12-20(32)26-21(34-22(2,3)35-26)10-15-16-9-18(27)17-8-14(30)6-7-23(17,4)25(16,28)19(31)11-24(15,26)5/h6-8,15-16,18-19,21,31H,9-12H2,1-5H3/t15-,16-,18-,19-,21+,23-,24-,25-,26+/m0/s1

InChI key

WJOHZNCJWYWUJD-IUGZLZTKSA-N

Gene Information

human ... NR3C1(2908)

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Fluocinonide BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:
  • Fluocinonide
  • Fluocinonide Ointment
  • Fluocinonide Cream

    • Biochem/physiol Actions

    Flucinonide is a fluorinated glucocorticid that is used as a topical anti-inflammatory agent. Recently, flucinonide and other fluorinated glucocorticolids were identified as smoothend agonists. Flucinonide induces expression of Gli-reporter luciferase in Shh-LIGHT2 cells.
    very potent corticosteroid

    Packaging

    Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

    Other Notes

    Sales restrictions may apply.

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    pictograms

    Skull and crossbonesHealth hazard
    GHS06,GHS08

    signalword

    Danger

    hcodes

    H300,H361

    Hazard Classifications

    Acute Tox. 2 Oral - Repr. 2

    Storage Class

    6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

    flash_point_f

    Not applicable

    flash_point_c

    Not applicable

    Regulatory Information

    涉药品监管产品

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    Global Trade Item Number

    SKUGTIN
    BP48904061835276318