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Merck
CN

C0415

Ciclopirox olamine

analytical standard

Synonym(s):

6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone ethanolammonium salt

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About This Item

Empirical Formula (Hill Notation):
C12H17NO2 · C2H7NO
CAS Number:
41621-49-2
Molecular Weight:
268.35
UNSPSC Code:
41116107
PubChem Substance ID:
329774787
EC Number:
255-464-9
MDL number:
MFCD00078997

Key Documents

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InChI key

MBRHNTMUYWQHMR-UHFFFAOYSA-N

InChI

1S/C12H17NO2.C2H7NO/c1-9-7-11(13(15)12(14)8-9)10-5-3-2-4-6-10;3-1-2-4/h7-8,10,15H,2-6H2,1H3;4H,1-3H2

SMILES string

NCCO.CC1=CC(=O)N(O)C(=C1)C2CCCCC2

grade

analytical standard

assay

≥97%

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
SLBN4527V
SLBK8794V
SLBF9186V
SLBF8062V
041M1460V

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Tsuyoshi Shimamura et al.
Antimicrobial agents and chemotherapy, 55(7), 3150-3155 (2011-05-11)
We developed a novel model of onychomycosis in which we observed fungi in the deep layer of the nail, and we used the model to evaluate the efficacy of two topical antifungal drugs. To establish an experimental, in vivo model
Fernanda Simas Corrêa Biancalana et al.
Mycopathologia, 172(4), 279-285 (2011-05-26)
Reference methods for antifungal susceptibility tests recommend the use of conidia as inoculum. However, some isolates produce few conidia, while the invasive form of filamentous fungi in general is hyphae making susceptibility tests infeaseble. These facts suggest that other than
Luis Nogueiras-Nieto et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 83(3), 370-377 (2012-12-04)
This work investigated the use of in situ gelling hydrogels based on polypseudorotaxanes of Pluronic F-127 and partially methylated β-cyclodextrin as aqueous nail lacquers. N-acetylcysteine and urea were incorporated as penetration enhancers. The formulations were tested for their ability to
Ciclopirox olamine: a hydroxypyridone antifungal agent.
B B Abrams et al.
Clinics in dermatology, 9(4), 471-477 (1991-10-01)
Mark D Minden et al.
American journal of hematology, 89(4), 363-368 (2013-11-26)
The antimycotic ciclopirox olamine is an intracellular iron chelator that has anticancer activity in vitro and in vivo. We developed an oral formulation of ciclopirox olamine and conducted the first-in-human phase I study of this drug in patients with relapsed
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