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Merck
CN

C0430

(−)-Cotinine solution

drug standard, 1.0 mg/mL in methanol

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About This Item

NACRES:
NA.24
PubChem Substance ID:
329774789
UNSPSC Code:
41116107
EC Number:
200-659-6
MDL number:
MFCD00077696

Key Documents

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Product Name

(−)-Cotinine solution, drug standard, 1.0 mg/mL in methanol

InChI key

UIKROCXWUNQSPJ-VIFPVBQESA-N

InChI

1S/C10H12N2O/c1-12-9(4-5-10(12)13)8-3-2-6-11-7-8/h2-3,6-7,9H,4-5H2,1H3/t9-/m0/s1

SMILES string

CN1[C@@H](CCC1=O)c2cccnc2

grade

drug standard

agency

EPA 1694

concentration

1.0 mg/mL in methanol

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

environmental
pharmaceutical (small molecule)

format

single component solution

storage temp.

2-8°C

Quality Level

100

Gene Information

human ... CYP1A2(1544), CYP2A6(1548)
mouse ... Cyp2a5(13087)

Related Categories

Application

(−)-Cotinine solution has been used as a standard in the analysis of nicotine in air samples using ultra performance liquid chromatography-mass spectrometry (UPLC-MS). (−)-Cotinine may be may used as an analytical reference standard for the quantification of the analyte in biological samples using high-performance liquid chromatography technique.
(−)-Cotinine solution has been used as a standard in the analysis of nicotine in air samples using ultra performance liquid chromatography-mass spectrometry (UPLC-MS).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

General description

(−)-Cotinine is a major metabolite of nicotine, widely used as a biochemical marker for to evaluate the exposure to environmental tobacco smoke, for the validation of abstinence smoking and to determine the percentage of active smoking behavior.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes

Storage Class

3 - Flammable liquids

wgk

WGK 2

flash_point_f

51.8 °F - closed cup

flash_point_c

11 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves

Regulatory Information

危险化学品
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Certificates of Analysis (COA)

Lot/Batch Number
0000474475
0000474475
0000379323
0000379323
0000443603

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Mohammad A Kaisar et al.
BMC neuroscience, 18(1), 71-71 (2017-10-13)
A sensitive, rapid and selective UHPLC-MS/MS method has been developed and validated for the quantification of Nicotine (NT) and Cotinine (CN) using Continine-d A linear response function was established for the range of concentrations 3-200 (r > 0.995) for NT and 3-600 ng/mL
A sensitive HPLC-ESI-MS-MS method for the determination of cotinine in urine
Apinan R, et al.
Journal of Chromatographic Science, 48(6), 460-465 (2010)
Rapid and sensitive high-performance liquid chromatographic determination of nicotine and cotinine in nonsmoker human and rat urines
Oddoze.C, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 708(1-2), 95-101 (1998)
A simple, sensitive, and rapid method for the determination of cotinine in urine by high-performance liquid chromatography with UV detection
Rabbaa-Khabbaz L, et al.
Journal of Chromatographic Science, 44(9), 535-538 (2006)
Assessment of nicotine for second hand smoke exposure in some public places in Romania by UPLC-MS
Bratan A, et al.
Chemistry Central Journal, 8(1), 29-29 (2014)
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