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Merck
CN

C2285000

Clobetasone butyrate

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

21-Chloro-9-fluoro-17-hydroxy-16-methylpregna-1,4-diene-3,11,20-trione 17-butyrate

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About This Item

Empirical Formula (Hill Notation):
C26H32ClFO5
CAS Number:
25122-57-0
Molecular Weight:
478.98
NACRES:
NA.24
PubChem Substance ID:
329774989
UNSPSC Code:
41116107
MDL number:
MFCD00133196

Key Documents

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Product Name

Clobetasone butyrate, European Pharmacopoeia (EP) Reference Standard

InChI

1S/C26H32ClFO5/c1-5-6-22(32)33-26(21(31)14-27)15(2)11-19-18-8-7-16-12-17(29)9-10-23(16,3)25(18,28)20(30)13-24(19,26)4/h9-10,12,15,18-19H,5-8,11,13-14H2,1-4H3/t15-,18-,19-,23-,24-,25-,26-/m0/s1

SMILES string

CCCC(=O)O[C@@]1([C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)C(=O)C[C@]12C)C(=O)CCl

InChI key

FBRAWBYQGRLCEK-AVVSTMBFSA-N

grade

pharmaceutical primary standard

API family

clobetasone

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

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Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Application

Clobetasone butyrate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

涉药品监管产品
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Ilknur Bostanci et al.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 15(3), 267-269 (2004-06-24)
Leptin, the obese gene product, is a 16-kDa peptide hormone secreted by adiposities. Systemic administration of exogenous glucocorticoids has been found to increase circulating leptin levels. In this study, we aimed to assess serum leptin in children with atopic dermatitis
Concomitant sensitivity to sodium metabisulfite and clobetasone butyrate in Trimovate cream.
D A Harrison et al.
Contact dermatitis, 46(5), 310-310 (2002-06-27)
Acute anterior uveitis.
André Curi et al.
Clinical evidence, (10)(10), 721-726 (2004-11-24)
Bavani Arun et al.
Pediatric dermatology, 27(3), 301-302 (2010-07-09)
We report the case of a 4-year-old boy who presented with a transient extensive eczematous eruption on the left side of his trunk and extremities, with clear demarcation in the midline. The eruption started to resolve without any sequelae in
Divya Mathews et al.
Ophthalmic plastic and reconstructive surgery, 26(3), 206-207 (2010-05-22)
A 32-year-old woman presented with cystic eyelid lesions accompanied by foul-smelling discharge. Excision biopsy showed that she had Darier disease, and she was referred to dermatology for further management. Despite clinically indolent-looking lesions, biopsy and histology allowed the diagnosis of
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