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C2734

5-Carboxytetramethylrhodamine

Name: 5-Carboxytetramethylrhodamine
Brand: SIAL

≥95% purity (HPLC), solid

Synonym(s):

5-TAMRA

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About This Item

Empirical Formula (Hill Notation):

C₂₅H₂₂N₂O₅

CAS Number:

91809-66-4

Molecular Weight:

430.45

UNSPSC Code:

12171500

NACRES:

NA.47

MDL number:

MFCD01073638

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Properties

Product Name

5-Carboxytetramethylrhodamine,

assay

≥95% (HPLC)

Quality Level

100

form

solid

solubility

water: slightly soluble

ε (extinction coefficient)

≥85000-97000 at 539-545 nm in methanol

fluorescence

λ_ex ~543 nm; λ_em ~570 nm in methanol

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

N(C)(C)c1cc2[o+]c3c(c(c2cc1)c4c(cc(cc4)C(=O)[O-])C(=O)O)ccc(c3)N(C)C

InChI

1S/C25H22N2O5/c1-26(2)15-6-9-18-21(12-15)32-22-13-16(27(3)4)7-10-19(22)23(18)17-8-5-14(24(28)29)11-20(17)25(30)31/h5-13H,1-4H3,(H-,28,29,30,31)

InChI key

YMZMTOFQCVHHFB-UHFFFAOYSA-N

Description

General description

An important fluorophore prepared in high purtity with a detection limit of TMR-labeled amino acids by capillary electrophoresis of approx. 600 molecules. Readily excited by the 546 nm spectral line from mercury-arc lamps used in fluorescent microscopes, and is intrinsically more photostable than fluorescein.

Application

5-Carboxytetramethylrhodamine has been used in fluorophore characterization.

Biochem/physiol Actions

5-Carboxytetramethylrhodamine can be covalently attached to the DNA and is thereby used in studies involving branched and duplex DNA/RNA structures. It is mainly used for single-molecule studies. 5-Carboxytetramethylrhodamine is also used for the labelling of oligosaccharide for laser-induced fluorescence detection.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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High-selectivity neural probe based on a Fabry-Perot optical filter and a CMOS silicon photodiodes array at visible wavelengths

Pimenta S, et al.

Journal of Biomedical Optics, 23(10), 105004-105004 (2018)

Two-dimensional combinatorial screening and the RNA Privileged Space Predictor program efficiently identify aminoglycoside-RNA hairpin loop interactions.

Dustin J Paul et al.

Nucleic acids research, 37(17), 5894-5907 (2009-09-04)

Herein, we report the identification of RNA hairpin loops that bind derivatives of kanamycin A, tobramycin, neamine, and neomycin B via two-dimensional combinatorial screening, a method that screens chemical and RNA spaces simultaneously. An arrayed aminoglycoside library was probed for

Direct current stimulation of endothelial monolayers induces a transient and reversible increase in transport due to the electroosmotic effect.

Limary M Cancel et al.

Scientific reports, 8(1), 9265-9265 (2018-06-20)

We investigated the effects of direct current stimulation (DCS) on fluid and solute transport across endothelial cell (EC) monolayers in vitro. Our motivation was transcranial direct current stimulation (tDCS) that has been investigated for treatment of neuropsychiatric disorders, to enhance

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Global Trade Item Number

SKU	GTIN
C2734-10MG	04061832341941