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Merck
CN

C2970000

Crotamiton

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

N-Ethyl-o-crotonotoluidide, N-Ethyl-N-(2-methylphenyl)-2-butenamide, Crotamiton

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About This Item

Linear Formula:
CH3CH=CHCON(C2H5)C6H4CH3
CAS Number:
483-63-6
Molecular Weight:
203.28
NACRES:
NA.24
PubChem Substance ID:
329775015
UNSPSC Code:
41116107
MDL number:
MFCD00026989

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InChI

1S/C13H17NO/c1-4-8-13(15)14(5-2)12-10-7-6-9-11(12)3/h4,6-10H,5H2,1-3H3/b8-4+

SMILES string

CCN(C(=O)\C=C\C)c1ccccc1C

InChI key

DNTGGZPQPQTDQF-XBXARRHUSA-N

grade

pharmaceutical primary standard

description

predominantly trans

API family

crotamiton

manufacturer/tradename

EDQM

refractive index

n20/D 1.54 (lit.)

bp

153-155 °C/13 mmHg (lit.)

density

0.987 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Crotamiton EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

235.4 °F - closed cup

flash_point_c

113 °C - closed cup

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Noriko Ohtaki et al.
The Journal of dermatology, 30(5), 411-416 (2003-05-30)
We report two cases of scabies treated with oral ivermectin (200 micro g/kg). Case 1, a 72-year-old man, developed crusted scabies with the use of oral corticosteroids due to a misdiagnosis by an earlier physician. The patient was successfully treated
E Dika et al.
Cutaneous and ocular toxicology, 25(3), 211-216 (2006-09-19)
Crotamiton is a topical drug used in the treatment of scabies and pruritus. We determined its percutaneous absorption following single and multiple dosing in normal skin. We used in vivo measurement of percutaneous absorption of [14C] crotamiton in a multidose
Rika Sekine et al.
Experimental dermatology, 21(3), 201-204 (2012-03-03)
Itch accompanies various skin diseases. As a number of mediators other than histamine can be involved in the itch sensation, H1 receptor antagonists are not necessarily effective in treating itch. External application of antipruritic drugs is occasionally used as an
Maria Wesołowska et al.
Wiadomosci parazytologiczne, 51(3), 253-256 (2006-08-18)
Demodex mites are common parasites in the hair follicles and in the pilosebaceous glands. Demodex folliculorum and D. brevis have been identified in humans and play a role in three facial conditions: Pityriasis folliculorum, rosacea-like demodicidosis and Demodicidosis gravis. The
F Forton et al.
The British journal of dermatology, 138(3), 461-466 (1998-05-15)
A standardized skin surface biopsy was performed in 34 patients suffering from skin diseases with high Demodex folliculorum density (Dd) > 5D/cm2 before, during and after topical treatment. The patients were randomized into six comparable groups to study six topical
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