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Merck
CN

C2970000

Crotamiton

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

N-Ethyl-o-crotonotoluidide, N-Ethyl-N-(2-methylphenyl)-2-butenamide, Crotamiton

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About This Item

Linear Formula:
CH3CH=CHCON(C2H5)C6H4CH3
CAS Number:
483-63-6
Molecular Weight:
203.28
NACRES:
NA.24
PubChem Substance ID:
329775015
UNSPSC Code:
41116107
MDL number:
MFCD00026989

Key Documents

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Product Name

Crotamiton, European Pharmacopoeia (EP) Reference Standard

InChI

1S/C13H17NO/c1-4-8-13(15)14(5-2)12-10-7-6-9-11(12)3/h4,6-10H,5H2,1-3H3/b8-4+

SMILES string

CCN(C(=O)\C=C\C)c1ccccc1C

InChI key

DNTGGZPQPQTDQF-XBXARRHUSA-N

grade

pharmaceutical primary standard

description

predominantly trans

API family

crotamiton

manufacturer/tradename

EDQM

refractive index

n20/D 1.54 (lit.)

bp

153-155 °C/13 mmHg (lit.)

density

0.987 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

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Application

Crotamiton EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

235.4 °F - closed cup

flash_point_c

113 °C - closed cup

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Habib Ansarin et al.
Dermatology online journal, 12(1), 19-19 (2006-04-28)
A wide range of clinical manifestations may be seen in scabies, from classic pruritic papules and burrows to secondary features such as impetigo. Bullus lesions are a less frequent. Twenty cases of scabies presenting with bullae have been reported so
N Nakada et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 61(7), 1739-1747 (2010-04-08)
The behavior of antibacterial triclosan, insect-repellent diethyltoluamide (DEET), anticonvulsant carbamazepine, and antipruritic crotamiton was investigated at two sewage treatment plants (STPs) to clarify their complete mass balance. Twenty-four-hour flow-proportional composite samples were collected from the influent and effluent of primary
Ahmed M Al-Arfaj et al.
The American journal of tropical medicine and hygiene, 76(5), 967-971 (2007-05-10)
A 31-year-old Saudi man was seen at an ear, nose, and throat clinic at Riyadh, Saudi Arabia, with bilateral itching in the external auditory canal. On otoscopic examination, the skin lining the ear canal was thickened with whitish sheets of
F Forton et al.
The British journal of dermatology, 138(3), 461-466 (1998-05-15)
A standardized skin surface biopsy was performed in 34 patients suffering from skin diseases with high Demodex folliculorum density (Dd) > 5D/cm2 before, during and after topical treatment. The patients were randomized into six comparable groups to study six topical
Allergic contact dermatitis due to crotamiton.
H Hara et al.
Contact dermatitis, 49(4), 219-219 (2004-03-05)
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