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C5548

Clobetasone butyrate

Name: Clobetasone butyrate
Brand: SIAL

≥98% purity, powder

Synonym(s):

21-Chloro-9-fluoro-17-hydroxy-16-methylpregna-1,4-diene-3,11,20-trione 17-butyrate

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About This Item

Empirical Formula (Hill Notation):

C₂₆H₃₂ClFO₅

CAS Number:

25122-57-0

Molecular Weight:

478.98

NACRES:

NA.47

PubChem Substance ID:

329775093

UNSPSC Code:

12171500

EC Number:

246-635-9

MDL number:

MFCD00133196

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Product Name

Clobetasone butyrate, ≥98%

Quality Level

200

assay

≥98%

form

powder

color

white to faint yellow cast

mp

90-100 °C

solubility

chloroform: 50 mg/mL, clear, faintly yellow

ε (extinction coefficient)

13.4 at 243 nm in chloroform

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

CCCC(=O)O[C@@]1([C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)C(=O)C[C@]12C)C(=O)CCl

InChI

1S/C26H32ClFO5/c1-5-6-22(32)33-26(21(31)14-27)15(2)11-19-18-8-7-16-12-17(29)9-10-23(16,3)25(18,28)20(30)13-24(19,26)4/h9-10,12,15,18-19H,5-8,11,13-14H2,1-4H3/t15-,18-,19-,23-,24-,25-,26-/m0/s1

InChI key

FBRAWBYQGRLCEK-AVVSTMBFSA-N

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General description

Clobetasone butyrate is a corticosteroid.

Application

Clobetasone butyrate has been used as an internal standard for the quantitative assay of clobetasol propionate.

Clobetasone butyrate has been used to analyze its bio-concentration factor (BCF) in Cyprinus carpio.

Biochem/physiol Actions

Clobetasone butyrate is a potent topical corticosteroid and is primarily used to treat atopic dermatitis (AD). Low dosage of this drug is used to treat dry eye in Sjogrens syndrome.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number

080H0754

080H0759

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Community Pharmacy - E-Book: Symptoms Diagnosis and Treatment (2011)

Safety and efficacy of 0.1% clobetasone butyrate eyedrops in the treatment of dry eye in Sjogren syndrome

Aragona P, et al.

European Journal of Ophthalmology, 23(3) (2013)

Liquid chromatography--tandem mass spectrometric assay for clobetasol propionate in human serum from patients with atopic dermatitis

Sparidans RW, et al.

Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 878(23), 2150-2154 (2010)

Fluticasone propionate 0.05% cream once daily versus clobetasone butyrate 0.05% cream twice daily in children with atopic dermatitis

Wolkerstorfer A, et al.

Journal of the American Academy of Dermatology, 39(2), 226-231 (1998)

Uptake and biological effects of synthetic glucocorticoids in common carp (Cyprinus carpio)

Nakayama K, et al.

Marine Pollution Bulletin, 85(2), 370-375 (2014)

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Global Trade Item Number

SKU	GTIN
C5548-100MG	04061832342054

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