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C7129

Citric acid monohydrate

Name: Citric acid monohydrate
Brand: SIAL

reagent grade, ≥98% (GC/titration), powder

Synonym(s):

2-hydroxy-1,2,3-propanetricarboxylic acid monohydrate

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About This Item

Linear Formula:

HOC(COOH)(CH₂COOH)₂ · H₂O

CAS Number:

5949-29-1

Molecular Weight:

210.14

NACRES:

NA.21

PubChem Substance ID:

24892935

UNSPSC Code:

12352100

EC Number:

201-069-1

MDL number:

MFCD00149972

Beilstein/REAXYS Number:

4018641

Assay:

≥98% (GC/titration)

Form:

powder

Grade:

reagent grade

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Product Name

Citric acid monohydrate, reagent grade, ≥98% (GC/titration)

grade

reagent grade

Quality Level

300

assay

≥98% (GC/titration)

form

powder

pKa

(1) 3.13, (2) 4.76, (3) 6.4

solubility

H₂O: 100 mg/mL, clear, colorless (Turbidity)

functional group

carboxylic acid

SMILES string

OC(CC(O)(C(O)=O)CC(O)=O)=O.O

InChI

1S/C6H8O7.H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);1H2

InChI key

YASYEJJMZJALEJ-UHFFFAOYSA-N

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Acids for Laboratory, Analysis, and Regulated Applications

General description

Citric acid monohydrate(CAM) is an organic acid. It can be produced by crystallization from mother liquor of citric acid solution at 20-25°C during citric acid synthesis. Its molar enthalpy of solution in water has been reported to be Δ_solH_m(298.15K, m = 0.0203molkg^-1) = (29061±123)Jmol^-1. An investigation of its crystal growth kinetics indicates that growth is linearly dependent on size.

Application

Citric acid monohydrate may be used:

To prepare citric acid solution employed in the acetone method of ⁶⁸Ga pre-purification and radiolabeling technique.
To prepare Tris-citrate buffer employed for the electrophoresis of bacterial enzymes.
To improve the release of diltiazem hydrochloride from melt extruded matrix tablets.

pictograms

GHS07

signalword

Warning

hcodes

H319,H335

pcodes

P261 - P264 - P271 - P280 - P304 + P340 + P312 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

flash_point_f

345.0 °F - closed cup

flash_point_c

173.9 °C - closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Size dependency of citric acid monohydrate growth kinetics.

Bravi M and Mazzarotta B.

Chemical Engineering Journal, 70(3), 203-207 (1998)

Methods of multilocus enzyme electrophoresis for bacterial population genetics and systematics.

R K Selander et al.

Applied and environmental microbiology, 51(5), 873-884 (1986-05-01)

A new automated NaCl based robust method for routine production of gallium-68 labeled peptides.

Michael K Schultz et al.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 76, 46-54 (2012-10-03)

A new NaCl based method for preparation of gallium-68 labeled radiopharmaceuticals has been adapted for use with an automated gallium-68 generator system. The method was evaluated based on 56 preparations of [(68)Ga]DOTATOC and compared to a similar acetone-based approach. Advantages

Citric acid monohydrate as a release-modifying agent in melt extruded matrix tablets.

Sandra U Schilling et al.

International journal of pharmaceutics, 361(1-2), 158-168 (2008-06-28)

Incomplete drug release and particle size-dependent dissolution performance can compromise the quality of controlled release matrix systems. The objective of the current study was to investigate the ability of citric acid monohydrate (CA MH) to enhance the release of diltiazem

New perspectives for citric acid production and application.

Soccol CR, et al.

Food Technology and Biotechnology, 44(2), 141-149 (2006)

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Global Trade Item Number

SKU	GTIN
C7129-500G	04061835321049
C7129-5KG	04061833511954
C7129-10MG	04061832996745
C7129-1KG	04061833511947
C7129-100G	04061833511930

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