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Merck
CN

D0720800

Dexchlorpheniramine maleate

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

S-(+)-Chlorpheniramine maleate salt, (S)-γ-(4-Chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine maleate salt

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About This Item

Empirical Formula (Hill Notation):
C16H19ClN2 · C4H4O4
CAS Number:
2438-32-6
Molecular Weight:
390.86
NACRES:
NA.24
PubChem Substance ID:
329798631
UNSPSC Code:
41116107
MDL number:
MFCD00079046

Key Documents

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InChI

1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t15-;/m0./s1

SMILES string

[H]\C(=C(/[H])C(O)=O)C(O)=O.CN(C)CC[C@@H](c1ccc(Cl)cc1)c2ccccn2

InChI key

DBAKFASWICGISY-DASCVMRKSA-N

grade

pharmaceutical primary standard

API family

dexchlorpheniramine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

Gene Information

human ... HRH1(3269)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Dexchlorpheniramine maleate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Fernando Bermejo et al.
Gastroenterologia y hepatologia, 31(10), 629-632 (2009-01-29)
Infliximab can provoke acute or delayed infusion reactions (IR) leading to treatment withdrawal. Our aim was to determine the frequency of IR in patients with inflammatory bowel disease receiving intravenous infliximab and premedicated with steroids and antihistaminics. We prospectively studied
[Protocol for inducing infliximab tolerance in a patient with psoriatic spondylarthritis].
R Gallardo et al.
Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria, 34(2), 94-96 (2010-03-23)
M Y Alabazi et al.
Die Pharmazie, 67(7), 611-617 (2012-08-15)
The purpose of this research was to formulate and evaluate a floating tablet formulation of dexchlorpheniramine maleate (DCPM) using full factorial design. A 32 factorial design (nine runs) was utilized to optimize the formulation, the contents of hydroxypropyl methyl cellulose
J Montoro et al.
Allergologia et immunopathologia, 33(4), 235-237 (2005-07-28)
Adult Still Disease (ASD) is a rare (incidence 1-1,6/1,000,000 in Europe) seronegative polyarthropathy diagnosed with clinical criteria, excluding other etiologies. Minocycline, a semisynthetic derivative of tetracycline, has been associated with many adverse effects. We present the case of a 18-years-old
[Systemic mastocytosis and perioperative management: a report of 2 cases].
N Calvo et al.
Revista espanola de anestesiologia y reanimacion, 57(3), 192-194 (2010-04-29)
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