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Merck
CN

D0730000

Dexpanthenol

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

D-Panthenol, (R)-(+)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide, (R)-2,4-Dihydroxy-3,3-dimethylbutyric 3-hydroxypropylamide, D-Pantothenyl alcohol, Dexpanthenol, Provitamin B

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About This Item

Empirical Formula (Hill Notation):
C9H19NO4
CAS Number:
81-13-0
Molecular Weight:
205.25
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329798633
MDL number:
MFCD00065006
Beilstein/REAXYS Number:
1724947

Key Documents

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Product Name

Dexpanthenol, European Pharmacopoeia (EP) Reference Standard

InChI

1S/C9H19NO4/c1-9(2,6-12)7(13)8(14)10-4-3-5-11/h7,11-13H,3-6H2,1-2H3,(H,10,14)/t7-/m0/s1

SMILES string

CC(C)(CO)[C@@H](O)C(=O)NCCCO

InChI key

SNPLKNRPJHDVJA-ZETCQYMHSA-N

biological source

synthetic

grade

pharmaceutical primary standard

agency

EP Reference Standard

API family

dexpanthenol

form

solid

manufacturer/tradename

EDQM

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

density

1.20 g/mL at 20 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

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Application

This European Pharmacopoeia reference standard is intended for use only as specifically prescribed in the European Pharmacopoeia.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Dexpanthenol, an alcoholic analog of pantothenic acid, can be potentially applied for skin wound healing application. It is utilized in multi-vitamin formulations, as a parenteral drug and certain cosmetic preparations. When absorbed by the skin, it is transformed into pantothenic acid (vitamin B5), which has implications in the biosynthesis of coenzyme A.

Other Notes

Sales restrictions may apply.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Simultaneous quantification of dexpanthenol and resorcinol from hair care formulation using liquid chromatography: method development and validation
De, Amit Kumar and Chowdhury, Partha Pratim and Chattapadhyay, Shyamaprasad
Scientifica, 2016(3), 983-988 (2016)
Anti-inflammatory and anti-oxidative effects of dexpanthenol on lipopolysaccharide induced acute lung injury in mice
Li-Mei W, et al.
Inflammation, 39(5), 1757-1763 (2016)
Simultaneous determination of mepyramine maleate, lidocaine hydrochloride, and dexpanthenol in pharmaceutical preparations by partial least-squares multivariate calibration
Aksu O, et al.
Analytical Letters, 39(4), 751-761 (2006)
Simultaneous determination of dexpanthenol, lidocaine hydrochloride, and mepyramine maleate in combined pharmaceutical gel by capillary electrophoresis
Akyil BG, et al.
Turkish Journal of Chemistry, 38(5), 756-764 (2014)
Dexpanthenol
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 2016(3), 2227-2228 (2017)
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