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Merck
CN

D1685

Docusate sodium

meets USP testing specifications

Synonym(s):

Docusate sodium salt, AOT, Bis(2-ethylhexyl) sulfosuccinate sodium salt, Sodium bis(2-ethylhexyl) sulfosuccinate, Sulfobutanedioic acid bis(2-ethylhexyl ester) sodium salt, Sulfosuccinic acid bis(2-ethylhexyl) ester sodium salt, ‘Dioctyl’ sulfosuccinate sodium salt

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About This Item

Empirical Formula (Hill Notation):
C20H37NaO7S
CAS Number:
577-11-7
Molecular Weight:
444.56
UNSPSC Code:
12161902
NACRES:
NA.21
PubChem Substance ID:
24893514
EC Number:
209-406-4
Beilstein/REAXYS Number:
4117588
MDL number:
MFCD00012455

Key Documents

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Product Name

Docusate sodium, meets USP testing specifications

InChI key

APSBXTVYXVQYAB-UHFFFAOYSA-M

InChI

1S/C20H38O7S.Na/c1-5-9-11-16(7-3)14-26-19(21)13-18(28(23,24)25)20(22)27-15-17(8-4)12-10-6-2;/h16-18H,5-15H2,1-4H3,(H,23,24,25);/q;+1/p-1

SMILES string

[Na+].CCCCC(CC)COC(=O)CC(C(=O)OCC(CC)CCCC)S([O-])(=O)=O

agency

meets USP testing specifications

description

anionic

assay

99.0-100.5% anhydrous basis

form

solid

mol wt

444.56 g/mol

technique(s)

protein quantification: suitable

application(s)

detection
pharmaceutical (small molecule)

Quality Level

200

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Application

Docusate sodium (DOSS, AOT) has been used in the preparation of the following:
  • Luminescent ceramics (phosphors).
  • Stock solution during the quantification of DOSS in sea food by using liquid chromatography tandem mass spectrometry (LC-MS/MS).
  • AOT-water-isooctane reverse micelle system
It has also been used in a study to understand its effect on protein bioactivity, when it is co-encapsulates with proteins in polymer based microsphere systems.
Forms reverse micelles in hydrocarbon solvents; Suitable for the solubilization of the major myelin transmembrane proteolipid

General description

Docusate sodium (sodium dioctylsulfosuccinate, DOSS) is commonly used as a surfactant, food additive and stool softener.

pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H315,H318

Hazard Classifications

Eye Dam. 1 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 2

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKDB0378
0000521782
0000521792
0000521782
0000521792

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Protein bioactivity and polymer orientation is affected by stabilizer incorporation for double-walled microspheres.
Kokai LE, et al.
J. Controlled Release, 141(2), 168-176 (2010)
Determination of dioctylsulfosuccinate in select seafoods using a QuEChERS extraction with liquid chromatography-triple quadrupole mass spectrometry.
Boyd BL, et al.
Laboratory Information Bulletin (2010)
Preparation and characterization of rare-earth-doped Y2O3 luminescent ceramics by the use of reverse micelles.
Graeve OA and Corral JO.
Opt. Mater., 29(1), 24-30 (2006)
Anna McNanley et al.
Female pelvic medicine & reconstructive surgery, 18(2), 82-85 (2012-03-29)
The goals of this study were to assess the effect of a standardized postoperative bowel regimen of over-the-counter medications on (1) time to first bowel movement (BM) and (2) pain level associated with first BM in subjects undergoing minimally invasive
Nader Emami et al.
Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale, 41(5), 316-319 (2012-10-25)
Docusate sodium (Colace) is an off-label ceruminolytic agent used to soften ear wax and relieve ear canal obstruction. At present, its effect on hearing in the presence of tympanic membrane (TM) perforation is not clear. The present study aimed to
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