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D2954000

Dobutamine hydrochloride

Name: Dobutamine hydrochloride
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

(±)-3,4-Dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-β-phenethylamine hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₂₃NO₃ · HCl

CAS Number:

49745-95-1

Molecular Weight:

337.84

NACRES:

NA.24

PubChem Substance ID:

329798764

UNSPSC Code:

41116107

MDL number:

MFCD00153795

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grade

pharmaceutical primary standard

API family

dobutamine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

Cl[H].CC(CCc1ccc(O)cc1)NCCc2ccc(O)c(O)c2

InChI

1S/C18H23NO3.ClH/c1-13(2-3-14-4-7-16(20)8-5-14)19-11-10-15-6-9-17(21)18(22)12-15;/h4-9,12-13,19-22H,2-3,10-11H2,1H3;1H

InChI key

BQKADKWNRWCIJL-UHFFFAOYSA-N

Gene Information

human ... ADRB1(153), ADRB2(154)

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Related Categories

Analytical Reference Materials for Pharma QC

Pharmacopeia & Metrological Institute Standards

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Dobutamine hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

pictograms

GHS08,GHS07

signalword

Warning

hcodes

H302 + H312 + H332,H361fd

pcodes

P201 - P280 - P301 + P312 + P330 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

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Assessment of changes in left ventricular systolic function with oesophageal Doppler.

X Monnet et al.

British journal of anaesthesia, 111(5), 743-749 (2013-06-27)

We tested the ability of mean acceleration (Acc) and peak velocity (V peak) of the aortic velocity signal measured by oesophageal Doppler to reflect left ventricular (LV) systolic performance. We included critically ill patients in whom a fluid challenge (n=25)

Myocardial perfusion and the J curve association between diastolic blood pressure and mortality.

Martin G Schultz et al.

American journal of hypertension, 26(4), 557-566 (2013-03-08)

The J-curve relationship between brachial diastolic blood pressure (DBP) and mortality is believed to be mediated through reduced myocardial perfusion. This study aimed to determine the relationship between DBP and subendocardial perfusion in patients with and without coronary artery disease

Cardiac stress test as a risk-stratification tool for posttransplant cardiac outcomes in diabetic kidney transplant recipients.

Neeraj Singh et al.

Transplantation, 94(12), 1224-1229 (2012-12-25)

The utility of cardiac stress testing as a risk-stratification tool before kidney transplantation remains debatable owing to discordance with coronary angiography and outcome yields at different centers. We conducted a retrospective study of 273 diabetic kidney transplant recipients from 2006

Termination of dobutamine infusion causes transient rebound left heart diastolic dysfunction in healthy elderly women but not in men: a cardiac magnetic resonance study.

Kiril A Ahtarovski et al.

American journal of physiology. Heart and circulatory physiology, 305(7), H1098-H1103 (2013-07-03)

Men and women are known to react differently to stress. Thus, stress cardiomyopathy almost solely strikes women. Stress cardiomyopathy is suggested to relate to sex differences in catecholamine reaction. Left heart function during dobutamine stress is well described, but sex-specific

Dobutamine stress echocardiography for the assessment of pressure-flow relationships of the pulmonary circulation.

Edmund M T Lau et al.

Chest, 146(4), 959-966 (2014-03-15)

Stress testing of the pulmonary circulation (via increasing pulmonary blood flow) can reveal abnormal mean pulmonary artery pressure-cardiac output (mPpa-Q) responses, which may facilitate early diagnosis of pulmonary vascular disease. We investigated the application of dobutamine stress echocardiography (DSE) for

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Global Trade Item Number

SKU	GTIN
D2954000	04061833800362

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