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Merck
CN

D4065

Dirithromycin

analytical standard, for drug analysis

Synonym(s):

[9S(R)]-9-Deoxo-11-deoxy-9,11-[imino[2-(2-methoxy)ethylidene]oxy]erthromycin; LY-237216

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About This Item

Empirical Formula (Hill Notation):
C42H78N2O14
CAS Number:
62013-04-1
Molecular Weight:
835.07
UNSPSC Code:
41116107
PubChem Substance ID:
329798792
MDL number:
MFCD00865041

Key Documents

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InChI

1S/C42H78N2O14/c1-15-29-42(10,49)37-24(4)32(43-30(56-37)21-52-17-16-50-13)22(2)19-40(8,48)36(58-39-33(45)28(44(11)12)18-23(3)53-39)25(5)34(26(6)38(47)55-29)57-31-20-41(9,51-14)35(46)27(7)54-31/h22-37,39,43,45-46,48-49H,15-21H2,1-14H3/t22-,23-,24+,25+,26-,27+,28+,29-,30-,31+,32+,33-,34+,35+,36-,37-,39+,40-,41+,42-/m1/s1

SMILES string

CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C4N[C@@H](COCCOC)OC([C@H]4C)[C@]1(C)O

InChI key

WLOHNSSYAXHWNR-KZYCBHIHSA-N

assay

≥95% (TLC)

form

solid

mol wt

apparent mol wt 835.1

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

Quality Level

100

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General description

Chemical structure: macrolide

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H317

pcodes

P280

Hazard Classifications

Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Regulatory Information

涉药品监管产品
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Certificates of Analysis (COA)

Lot/Batch Number
MKCG0791
MKCD2497
MKBV6004V
MKBV2310V
MKBQ6449V

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G G Zhanel et al.
Drugs, 61(4), 443-498 (2001-04-28)
The first macrolide, erythromycin A, demonstrated broad-spectrum antimicrobial activity and was used primarily for respiratory and skin and soft tissue infections. Newer 14-, 15- and 16-membered ring macrolides such as clarithromycin and the azalide, azithromycin, have been developed to address
W B Shelley et al.
Journal of the American Academy of Dermatology, 40(1), 69-72 (1999-01-28)
In an open uncontrolled study of 3 patients with balanitis xerotica obliterans we have observed significant improvement after long-term systemic antibiotic therapy. Two of the patients noticed softening of the skin as well as disappearance of pruritus, tenderness, and inflammatory
In vitro activity of azithromycin and dirithromycin against axenic Entamoeba histolytica.
S Ranque et al.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 23(12), 932-933 (2004-12-16)
P A Moore
Journal of the American Dental Association (1939), 130(9), 1341-1343 (1999-09-24)
When treating oral infections, clinicians have used the macrolide antibiotic erythromycin as an alternative antibiotic for patients who have documented allergic reactions to penicillins. In this article, the author reports on his assessment of the pharmacology of erythromycin and the
S A McConnell et al.
The Journal of antimicrobial chemotherapy, 43(5), 733-736 (1999-06-26)
Twelve healthy volunteers were enrolled in an open-label, randomized, crossover study. Subjects received single doses of theophylline (5 mg/kg) alone and after a 10 day course of dirithromycin (two 250 mg tablets od). The study phases were separated by a
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