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Merck
CN

D7439

Dihydroartemisinin

analytical standard, mixture of α and β isomers

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About This Item

Empirical Formula (Hill Notation):
C15H24O5
Molecular Weight:
284.35
NACRES:
NA.24
PubChem Substance ID:
329798850
UNSPSC Code:
41116107
MDL number:
MFCD28384156

Key Documents

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InChI

1S/C15H24O5/c1-8-4-5-10-9(2)12(16)18-13-15(10)11(8)6-14(3,7-17-13)19-20-15/h8-13,16H,4-7H2,1-3H3/t8-,9-,10+,11+,12?,13+,14+,15+/m1/s1

SMILES string

C[C@H]1C(O)O[C@@]2([H])[C@@]3(OO4)[C@](CC[C@]4(C)O2)([H])[C@H](C)CC[C@]31[H]

InChI key

DJGUTYJDEZGRGH-NJEKVMANSA-N

grade

analytical standard

assay

≥97% (TLC)

form

powder

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Quality Level

200

Related Categories

General description

Antimalarial; antipsoriasis; anti-inflammatory.
Dihydroartemisinin is the major metabolite of the antimalarial agent, artemether. It is highly efficient against both drug-sensitive and drug-resistant strains of Plasmodium falciparum.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Preparation Note

artemisia plant extract

Disclaimer

Protect from light.

pictograms

FlameEnvironment
GHS02,GHS09

signalword

Danger

hcodes

H242,H411

Hazard Classifications

Aquatic Chronic 2 - Org. Perox. C

Storage Class

5.2 - Organic peroxides and self-reacting hazardous materials

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

监管及禁止进口产品
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Certificates of Analysis (COA)

Lot/Batch Number
0000454437
0000454437
0000375586
0000375586
0000254398

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Selective determination, in plasma, of artemether and its major metabolite, dihydroartemisinin, by high-performance liquid chromatography with ultraviolet detection
Thomas GC, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 583(1), 131-136 (1992)
Anne Marijon et al.
Malaria journal, 13, 501-501 (2014-12-18)
Improving management of patients suffering from cerebral malaria is needed to reduce the devastating mortality and morbidity of the disease in endemic areas. Intravenous artesunate is currently the first-line treatment, but the lack of material and skills in the field
Zenglei Wang et al.
PloS one, 9(4), e93825-e93825 (2014-04-17)
Malaria elimination/eradication campaigns emphasize interruption of parasite transmission as a priority strategy. Screening for new drugs and vaccines against gametocytes is therefore urgently needed. However, current methods for sexual stage drug assays, usually performed by counting or via fluorescent markers
Aditya S Paul et al.
Nature communications, 11(1), 3532-3532 (2020-07-17)
Asexual proliferation of the Plasmodium parasites that cause malaria follows a developmental program that alternates non-canonical intraerythrocytic replication with dissemination to new host cells. We carried out a functional analysis of the Plasmodium falciparum homolog of Protein Phosphatase 1 (PfPP1)
Harvie P Portugaliza et al.
eLife, 9 (2020-10-22)
Malaria transmission is dependent on the formation of gametocytes in the human blood. The sexual conversion rate, the proportion of asexual parasites that convert into gametocytes at each multiplication cycle, is variable and reflects the relative parasite investment between transmission
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