Key Documents

D8064

4-(2-(6-(Dibutylamino)-2-naphthalenyl)ethenyl)-1-(3-sulfopropyl)pyridinium hydroxide inner salt

Name: 4-(2-(6-(Dibutylamino)-2-naphthalenyl)ethenyl)-1-(3-sulfopropyl)pyridinium hydroxide inner salt
Brand: SIAL

≥95% purity (HPLC), solid

Synonym(s):

Di-4-ANEPPS

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About This Item

Empirical Formula (Hill Notation):

C₂₈H₃₆N₂O₃S

CAS Number:

90134-00-2

Molecular Weight:

480.66

UNSPSC Code:

12171500

PubChem Substance ID:

329798855

NACRES:

NA.47

MDL number:

MFCD03453609

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Product Name

4-(2-(6-(Dibutylamino)-2-naphthalenyl)ethenyl)-1-(3-sulfopropyl)pyridinium hydroxide inner salt, ≥95% (HPLC), solid

Quality Level

100

assay

≥95% (HPLC)

form

solid

mol wt

480.66

technique(s)

titration: suitable

color

orange to dark red

solubility

DMF: soluble, DMSO: soluble, ethanol: soluble

ε (extinction coefficient)

≥38000 at 493-499 nm in methanol

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

2-8°C

SMILES string

CCCCN(CCCC)c1ccc2cc(\C=C\c3cc[n+](CCCS([O-])(=O)=O)cc3)ccc2c1

InChI

1S/C28H36N2O3S/c1-3-5-17-30(18-6-4-2)28-13-12-26-22-25(10-11-27(26)23-28)9-8-24-14-19-29(20-15-24)16-7-21-34(31,32)33/h8-15,19-20,22-23H,3-7,16-18,21H2,1-2H3

InChI key

HAPJROQJVSPKCJ-UHFFFAOYSA-N

Related Categories

Clinical & Diagnostics

Hematology Stains

Histology Stains

Tissue Diagnostics

Application

4-(2-(6-(Dibutylamino)-2-naphthalenyl)ethenyl)-1-(3-sulfopropyl)pyridinium hydroxide inner salt has been used as a voltage sensitive dye in cardiac cells.

Biochem/physiol Actions

Membrane potential dye that responds to changes in membrane potential monitored by fluorescence excitation changes at 440 and 505 nm; correlated to changes in membrane potential of the cell.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Overall Assay of Neuronal Signal Propagation Pattern With Long-Term Potentiation (LTP) in Hippocampal Slices From the CA1 Area With Fast Voltage-Sensitive Dye Imaging.

Yoko Tominaga et al.

Frontiers in cellular neuroscience, 12, 389-389 (2018-11-09)

Activity-dependent changes in the input-output (I-O) relationship of a neural circuit are central in the learning and memory function of the brain. To understand circuit-wide adjustments, optical imaging techniques to probe the membrane potential at every component of neurons, such

Optogenetic Manipulation of Postsynaptic cAMP Using a Novel Transgenic Mouse Line Enables Synaptic Plasticity and Enhances Depolarization Following Tetanic Stimulation in the Hippocampal Dentate Gyrus.

Thomas T Luyben et al.

Frontiers in neural circuits, 14, 24-24 (2020-06-26)

cAMP is a positive regulator tightly involved in certain types of synaptic plasticity and related memory functions. However, its spatiotemporal roles at the synaptic and neural circuit levels remain elusive. Using a combination of a cAMP optogenetics approach and voltage-sensitive

Characterization of an extensive transverse tubular network in sheep atrial myocytes and its depletion in heart failure.

Katharine M Dibb et al.

Circulation. Heart failure, 2(5), 482-489 (2009-10-08)

In ventricular myocytes, the majority of structures that couple excitation to the systolic rise of Ca(2+) are located at the transverse tubular (t-tubule) membrane. In the failing ventricle, disorganization of t-tubules disrupts excitation contraction coupling. The t-tubule membrane is virtually

Probing the orientational distribution of dyes in membranes through multiphoton microscopy.

James E Reeve et al.

Biophysical journal, 103(5), 907-917 (2012-09-27)

Numerous dyes are available or under development for probing the structural and functional properties of biological membranes. Exogenous chromophores adopt a range of orientations when bound to membranes, which have a drastic effect on their biophysical behavior. Here, we present

Modeling Atrial Fibrillation using Human Embryonic Stem Cell-Derived Atrial Tissue.

Zachary Laksman et al.

Scientific reports, 7(1), 5268-5268 (2017-07-15)

Since current experimental models of Atrial Fibrillation (AF) have significant limitations, we used human embryonic stem cells (hESCs) to generate an atrial-specific tissue model of AF for pharmacologic testing. We generated atrial-like cardiomyocytes (CMs) from hESCs which preferentially expressed atrial-specific

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Global Trade Item Number

SKU	GTIN
D8064-5MG	04061832342665

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