D8809
USP/NF
meets USP testing specifications
solid
neoplastics
DNA synthesis | interferes
2-8°C
Cl.COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(C)=O
1S/C27H29NO10.ClH/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33;/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3;1H/t10-,14-,16-,17-,22+,27-;/m0./s1
GUGHGUXZJWAIAS-QQYBVWGSSA-N
human ... TOP2A(7153)
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1 of 3
This Item | PHR3433 | 178220 |
---|---|---|
neoplastics | - | - |
DNA synthesis | interferes | - | - |
2-8°C | -10 to -25°C | 2-8°C |
200 | 300 | 100 |
human ... TOP2A(7153) | - | - |
Danger
Acute Tox. 3 Oral - Carc. 2 - Muta. 2 - Repr. 1B
6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK 3
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Per Martindale The Extra Pharmacopoeia, 31st edition, p. 565-3 (1996), this compound is freely soluble in water and methyl alcohol. It is slightly soluble in alcohol, very slightly soluble in chloroform, and practically insoluble in acetone.
Per Martindale The Extra Pharmacopoeia, 31st edition, p. 565-3 (1996), stability in solution appeared to be partly related to pH. Daunorubicin was more stable as the pH of the mixture became more acidic, with the best stability in glucose injection solution (5%) with a pH of 4.5 Although daunorubicin solutions are degraded by light, the effect is reported not to be significant at concentrations of 500 ug/mL or above. However, below this concentration, precautions should be taken to protect solutions from light, and storage should be in polyethylene or polypropylene containers to minimize adsorptive losses.
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