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D9680

1,4-Dithioerythritol

Name: 1,4-Dithioerythritol
Brand: SIAL

BioXtra, ≥99.0%

Synonym(s):

erythro-1,4-Dimercapto-2,3-butanediol, erythro-2,3-Dihydroxy-1,4-butanedithiol, Cleland’s reagent, DTE

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About This Item

Linear Formula:

HSCH₂CH(OH)CH(OH)CH₂SH

CAS Number:

6892-68-8

Molecular Weight:

154.25

UNSPSC Code:

12161504

NACRES:

NA.31

PubChem Substance ID:

24894319

EC Number:

229-998-8

Beilstein/REAXYS Number:

1719756

MDL number:

MFCD00063750

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product line

BioXtra

Quality Level

200

assay

≥99.0%

form

powder

reaction suitability

reagent type: reductant

impurities

Insoluble matter, passes filter test, ≤0.0005% Phosphorus (P)

pH

4.5-6.5 (0.1 M in H₂O)

mp

82-84 °C (lit.)

solubility

H₂O: 0.1 M, clear, colorless

anion traces

sulfate (SO₄^2-): ≤0.005%

cation traces

Al: ≤0.0005%, Ca: ≤0.001%, Cu: ≤0.0005%, Fe: ≤0.0005%, K: ≤0.05%, Mg: ≤0.0005%, Na: ≤0.005%, Pb: ≤0.001%, Zn: ≤0.001%

absorption

≤0.4 at 280 in H₂O at 0.1 M, ≤0.6 at 260 in H₂O at 0.1 M

storage temp.

2-8°C

SMILES string

O[C@@H](CS)[C@H](O)CS

InChI

1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4+

InChI key

VHJLVAABSRFDPM-ZXZARUISSA-N

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Related Categories

Biochemicals

Chelating & Reducing Agents for Research

Chemistry & Biochemicals

High-Purity Biochemicals and Reagents

Application

Reagent for maintaining −SH groups in the reduced state; quantitatively reduces disulfides.

pictograms

GHS07

signalword

Warning

hcodes

H302,H412

pcodes

P273 - P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

0000541432

0000427059

0000427058

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Vitamin C Deficiency Reduces Muscarinic Receptor Coronary Artery Vasoconstriction and Plasma Tetrahydrobiopterin Concentration in Guinea Pigs.

Gry Freja Skovsted et al.

Nutrients, 9(7) (2017-07-04)

Vitamin C (vitC) deficiency is associated with increased cardiovascular disease risk, but its specific interplay with arteriolar function is unclear. This study investigates the effect of vitC deficiency in guinea pigs on plasma biopterin status and the vasomotor responses in

Genome-scale mapping of DNase I hypersensitivity.

Sam John et al.

Current protocols in molecular biology, Chapter 27, Unit 21-Unit 21 (2013-07-04)

DNase I-seq is a global and high-resolution method that uses the nonspecific endonuclease DNase I to map chromatin accessibility. These accessible regions, designated as DNase I hypersensitive sites (DHSs), define the regulatory features, (e.g., promoters, enhancers, insulators, and locus control

Highly sensitive gold nanoparticle-based colorimetric sensing of mercury(II) through simple ligand exchange reaction in aqueous media.

Yang-Rae Kim et al.

ACS applied materials & interfaces, 2(1), 292-295 (2010-04-02)

A strategy for the rational design of a novel colorimetric sensor based on dithioerythritol-modified gold nanoparticles for the selective recognition of Hg2+ in aqueous media is presented. This approach relies on the combination of gold nanoparticles with Hg2+ through sulfur-Hg2+-sulfur

Inhibition of mitochondrial carnitine/acylcarnitine transporter by H(2)O(2): molecular mechanism and possible implication in pathophysiology.

Annamaria Tonazzi et al.

Chemico-biological interactions, 203(2), 423-429 (2013-02-14)

H(2)O(2) inhibits the [(3)H]carnitine/carnitine antiport catalysed by the mitochondrial carnitine/acylcarnitine transporter reconstituted in proteoliposomes. The inhibition was reversed by dithioerythritol, N-acetylcysteine and L-cysteine. Inhibition time-dependence revealed a faster and a slower reaction stages with orders of reaction of 1.0 and

A pH-metric, UV, NMR, and X-ray crystallographic study on arsenous acid reacting with dithioerythritol.

András Kolozsi et al.

Inorganic chemistry, 47(9), 3832-3840 (2008-04-03)

The aqueous solutions of arsenous acid with the meso and racemic forms of 1,4-dithiol-butane-2,3-diol, namely, dithioerythritol (dte) and dithiothreitol (dtt), respectively, were titrated pH-metrically in different molar ratios. The p K a values determined for As(OH) 3, and dtt were

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Global Trade Item Number

SKU	GTIN
D9680-5G	04061833610619
D9680-1G	04061833590973

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