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E0753

4-Ethoxymethylene-2-phenyl-2-oxazolin-5-one

Name: 4-Ethoxymethylene-2-phenyl-2-oxazolin-5-one
Brand: SIAL

analytical standard, for drug analysis

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About This Item

Empirical Formula (Hill Notation):

C₁₂H₁₁NO₃

CAS Number:

15646-46-5

Molecular Weight:

217.22

NACRES:

NA.24

PubChem Substance ID:

329798987

UNSPSC Code:

41116107

EC Number:

239-713-9

MDL number:

MFCD00003204

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Properties

Quality Level

200

assay

≥90% (HPLC)

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

94-96 °C (dec.) (lit.)

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

storage temp.

2-8°C

SMILES string

CCO\C=C1/N=C(OC1=O)c2ccccc2

InChI

1S/C12H11NO3/c1-2-15-8-10-12(14)16-11(13-10)9-6-4-3-5-7-9/h3-8H,2H2,1H3/b10-8-

InChI key

SJHPCNCNNSSLPL-NTMALXAHSA-N

Description

Application

4-Ethoxymethylene-2-phenyl-2-oxazolin-5-one has been used as a haptenizing agent, which can induce an inflammatory reaction in adult zebrafish intestinal tissues and this can be used as a model for gene expression studies of the two forms of inflammatory bowel disease like Crohn′s disease and ulcerative colitis.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Oxazolone sensitizing agent

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pictograms

GHS07

signalword

Warning

hcodes

H317

pcodes

P280

Hazard Classifications

Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Delayed Gut Colonization Shapes Future Allergic Responses in a Murine Model of Atopic Dermatitis.

Amalie W Arildsen et al.

Frontiers in immunology, 12, 650621-650621 (2021-04-06)

Epidemiological studies have long reported that perturbations of the childhood microbiome increase the risk of developing allergies, but a causal relationship with atopic dermatitis remains unclear. Here we colonized germ-free mice at birth or at one or eight week-of-age to

Dietary prebiotics promote intestinal Prevotella in association with a low-responding phenotype in a murine oxazolone-induced model of atopic dermatitis.

Ann Laigaard et al.

Scientific reports, 10(1), 21204-21204 (2020-12-05)

Atopic dermatitis is a chronic eczema commonly observed among children in Western countries. The gut microbiota is a significant factor in the pathogenesis, and ways to promote intestinal colonizers with anti-inflammatory capabilities are therefore favorable. The present study addressed the

Comparison of two chemically-induced colitis-models in adult zebrafish, using optical projection tomography and novel transcriptional markers

Haarder S, et al.

The Open Immunology Journal, 6, 154-154 (2016)

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Global Trade Item Number

SKU	GTIN
E0753-5G	04061832849706
E0753-1G	04061826035566
E0753-10G	04061832849690