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Merck
CN

E4754

Ethacrynic acid

analytical standard, for drug analysis

Synonym(s):

(2,3-Dichloro-4-[2-methylenebutyryl]phenoxy)acetic acid

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About This Item

Empirical Formula (Hill Notation):
C13H12Cl2O4
CAS Number:
58-54-8
Molecular Weight:
303.14
UNSPSC Code:
41116107
PubChem Substance ID:
24894577
EC Number:
200-384-1
MDL number:
MFCD00056693

Key Documents

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technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

ClC1=C(Cl)C(C(C(CC)=C)=O)=CC=C1OCC(O)=O

InChI

1S/C13H12Cl2O4/c1-3-7(2)13(18)8-4-5-9(12(15)11(8)14)19-6-10(16)17/h4-5H,2-3,6H2,1H3,(H,16,17)

InChI key

AVOLMBLBETYQHX-UHFFFAOYSA-N

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Nanomedicine : nanotechnology, biology, and medicine, 8(7), 1088-1095 (2012-01-18)
Interstitial transport of large molecules and nanoparticles is an important concern in nanomedicine-mediated cancer treatment. To that end, the current study was proposed to improve the transport through enlargement of extracellular space by treating tumors with hypertonic solution of mannitol
Takatoshi Inaoka et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(45), 18390-18395 (2011-10-26)
Cochlear hair cells convert sound vibration into electrical potential, and loss of these cells diminishes auditory function. In response to mechanical stimuli, piezoelectric materials generate electricity, suggesting that they could be used in place of hair cells to create an
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Chemistry (Weinheim an der Bergstrasse, Germany), 17(28), 7806-7816 (2011-06-18)
Platinum-based cancer drugs, such as cisplatin, are highly effective chemotherapeutic agents used extensively for the treatment of solid tumors. However, their effectiveness is limited by drug resistance, which, in some cancers, has been associated with an overexpression of pi class
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Neurobiology of disease, 45(3), 862-870 (2011-12-27)
TAR DNA-binding protein 43 (TDP-43) is a major component of ubiquitin-positive inclusion of TDP-43 proteinopathies including amyotrophic lateral sclerosis and frontotemporal lobar degeneration with ubiquitinated inclusions, which is now referred to as FTLD-TDP. TDP-43 in the aberrant inclusion is known
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