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F1427

Florfenicol

Name: Florfenicol
Brand: SIAL

analytical standard, for drug analysis

Synonym(s):

Aquafen, Nuflor, SCH-25298, [R-(R*,S*)]-2,2-Dichloro-N-[1-(fluoromethyl)-2-hydroxy-2-[4-(methylsulfonyl)phenyl]ethyl]acetamide

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About This Item

Empirical Formula (Hill Notation):

C₁₂H₁₄Cl₂FNO₄S

CAS Number:

73231-34-2

Molecular Weight:

358.21

NACRES:

NA.24

PubChem Substance ID:

329799680

UNSPSC Code:

41116107

MDL number:

MFCD00864834

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Properties

Quality Level

100

form

solid

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

CS(=O)(=O)c1ccc(cc1)[C@@H](O)[C@@H](CF)NC(=O)C(Cl)Cl

InChI

1S/C12H14Cl2FNO4S/c1-21(19,20)8-4-2-7(3-5-8)10(17)9(6-15)16-12(18)11(13)14/h2-5,9-11,17H,6H2,1H3,(H,16,18)/t9-,10-/m1/s1

InChI key

AYIRNRDRBQJXIF-NXEZZACHSA-N

Description

General description

Florfenicol is a broad-spectrum amphenicol antibiotic used against diseases affecting domestic and wild animals.

Application

The analytical standard can be used as follows:

To measure florfenicol and its main metabolite florfenicol amine in tilapia meat by solid phase extraction (SPE) and ultra high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS)
Multi-residue analysis of three amfenicols in animal feed samples by HPLC-MS/MS method, following European Commission Decision 2002/657/EC(2)Determination of florfenicol in different animal feedstuff samples by thin layer chromatography (TLC) coupled with HPLC-UV detection
Residue analysis of florfenicol in broiler meat and liver samples by a reversed phase-HPLC method in combination with UV detection at 223 nm
Competitive indirect-chemiluminescent enzyme-linked immunosorbent assay (CL-ELISA) based quantitative analysis of florfenicol and its major metabolite florfenicol amine in chicken muscle samples, validated as per Commission Decision 2002/657/EC

Other Notes

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

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Danger

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - STOT RE 1

target_organs

Liver,Brain,Testes,Spinal cord,Blood,gallbladder

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

涉药品监管产品

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A Novel and Validated Protocol for Performing MIC Tests to Determine the Susceptibility of

Sergio Contreras-Lynch et al.

Frontiers in microbiology, 8, 1255-1255 (2017-07-22)

This paper presents a validated protocol, using a novel, specifically formulated medium, to perform broth microdilution antimicrobial susceptibility assays of the salmonid bacterial pathogen

Novel single-stranded DNA binding protein-assisted fluorescence aptamer switch based on FRET for homogeneous detection of antibiotics.

Ye Wang et al.

Biosensors & bioelectronics, 87, 508-513 (2016-09-07)

Herein, a smart single-stranded DNA binding protein (SSB)-assisted fluorescence aptamer switch based on fluorescence resonance energy transfer (FRET) was designed. The FRET switch was synthesized by connecting SSB labeled quantum dots (QDs@SSB) as donor with aptamer (apt) labeled gold nanoparticles

Whole blood transcriptomic analysis of beef cattle at arrival identifies potential predictive molecules and mechanisms that indicate animals that naturally resist bovine respiratory disease.

Matthew A Scott et al.

PloS one, 15(1), e0227507-e0227507 (2020-01-14)

Bovine respiratory disease (BRD) is a multifactorial disease complex and the leading infectious disease in post-weaned beef cattle. Clinical manifestations of BRD are recognized in beef calves within a high-risk setting, commonly associated with weaning, shipping, and novel feeding and

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Global Trade Item Number

SKU	GTIN
F1427-500MG	04061835564101