F8639
Famprofazone
analytical standard
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About This Item
Empirical Formula (Hill Notation):
C24H31N3O
CAS Number:
Molecular Weight:
377.52
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24
grade
analytical standard
Quality Level
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
veterinary
format
neat
SMILES string
CC(C)C1=C(CN(C)C(C)Cc2ccccc2)N(C)N(c3ccccc3)C1=O
InChI
1S/C24H31N3O/c1-18(2)23-22(17-25(4)19(3)16-20-12-8-6-9-13-20)26(5)27(24(23)28)21-14-10-7-11-15-21/h6-15,18-19H,16-17H2,1-5H3
InChI key
GNUXVOXXWGNPIV-UHFFFAOYSA-N
General description
Famprofazone is a pyrazole derivative and belongs to the class of non-steroidal anti-inflammatory drugs. It is widely used as an analgesic and antipyretic in medical applications.
Application
Famprofazone may be used as an analytical reference standard for the quantification of the analyte in biological samples using liquid chromatography coupled to tandem mass spectrometry.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Signal Word
Warning
Hazard Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
监管及禁止进口产品
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Forensic Science
Handbook of Analytical Chemistry, 6(7), 311-322 (2011)
H S Shin
Chirality, 9(1), 52-58 (1997-01-01)
Following administration of famprofazone to humans, the stereoselective metabolism from the drug to its known metabolites (+,-)-ephedrine, (+,-)-pseudoephedrine, (+,-)-norephedrine, (+,-)-norpseudoephedrine, (+,-)-p-hyroxyamphetamine, (+,-)-p-hydroxymethamphetamine, and (+,-)-p-hydroxynorephedrine was studied. The enantiomers of the metabolites were derivatized with alpha-methoxy-alpha -(trifluoromethyl)-phenylacetyl chloride (MPTA.Cl) as the
F Musshoff et al.
International journal of legal medicine, 111(6), 305-308 (1998-11-24)
After a traffic accident a 32-year-old man was suspected of having previously taken an illegal drug. An immunochemical screening procedure revealed positive results for amphetamines in both urine and blood samples. The preliminary test was confirmed by GC/MS and both
Brandy Greenhill et al.
Journal of analytical toxicology, 27(7), 479-484 (2003-11-11)
There are a several drugs that lead to the production of methamphetamine and/or amphetamine in the body which are subsequently excreted in the urine. These drugs raise obvious concerns when interpreting positive amphetamine drug testing results. Famprofazone is an analgesic
H S Shin et al.
Journal of chromatography. B, Biomedical applications, 661(2), 255-261 (1994-11-18)
Detection and identification of famprofazone and its metabolite, p-hydroxydesmethylfamprofazone, were described. The identity of the new metabolite was confirmed by comparing its mass spectrum and gas chromatographic retention time with that of the synthetic standard and its derivatives. Unchanged famprofazone
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