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G0340000

Glipizide

Name: Glipizide
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

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Synonym(s):

1-Cyclohexyl-3-{4-[2-(5-methylpyrazine-2-carboxamido)ethyl]phenylsulfonyl}urea

Empirical Formula (Hill Notation):

C₂₁H₂₇N₅O₄S

CAS Number:

29094-61-9

Molecular Weight:

445.54

MDL number:

MFCD00072159

PubChem Substance ID:

329799809

NACRES:

NA.24

grade

pharmaceutical primary standard

API family

glipizide

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

Cc1cnc(cn1)C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)NC3CCCCC3

InChI

1S/C21H27N5O4S/c1-15-13-24-19(14-23-15)20(27)22-12-11-16-7-9-18(10-8-16)31(29,30)26-21(28)25-17-5-3-2-4-6-17/h7-10,13-14,17H,2-6,11-12H2,1H3,(H,22,27)(H2,25,26,28)

InChI key

ZJJXGWJIGJFDTL-UHFFFAOYSA-N

Gene Information

human ... ABCC8(6833) , KCNJ11(3767)

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Analytical Reference Standards

Pharmacopeia & Metrological Institute Standards

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Glipizide EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Product No.

Description

Pricing

1292609

1292610

1292631

PHR1813

PHR1814

PHR1815

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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In vitro characterization of a novel polymeric system for preparation of amorphous solid drug dispersions.

Zahra N Mahmoudi et al.

The AAPS journal, 16(4), 685-697 (2014-05-03)

Preparation of amorphous solid dispersions using polymers is a commonly used formulation strategy for enhancing the solubility of poorly water-soluble drugs. However, often a single polymer may not bring about a significant enhancement in solubility or amorphous stability of a

Glipizide: an oral hypoglycemic drug.

G Wensing

The American journal of the medical sciences, 298(1), 69-71 (1989-07-01)

[The clinical pharmacology of Minidiab (glipizide) (a review of the literature)].

A V Shcherbak

Likars'ka sprava, (1)(1), 28-33 (1993-01-01)

[Glipizide--a short-acting sulphonylurea derivative].

J Ogonowski

Przeglad lekarski, 53(9), 666-667 (1996-01-01)

Glipizide is a second generation of sulphonylurea compound, effective in lowering of blood glucose, well-tolerated as well as safe during long-term treatment. Glipizide is the agent characterized by rapid pharmacological action. It is indicated both in monotherapy and combined treatment

Glipizide. A review of the pharmacoeconomic implications of the extended-release formulation in type 2 diabetes mellitus.

R H Foster et al.

PharmacoEconomics, 18(3), 289-306 (2001-01-09)

Glipizide is a second generation sulphonylurea agent that is available in a Gastrointestinal Therapeutic System (GITS) extended-release formulation. Glipizide GITS provides more stable plasma drug concentrations than the immediate-release formulation and the once-daily regimen may optimise patient compliance. In patients

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