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Merck
CN

G6895

Glafenine

analytical standard

Synonym(s):

1-Glyceryl N-(7-chloro-4-quinolyl)anthranilate

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About This Item

Empirical Formula (Hill Notation):
C19H17ClN2O4
CAS Number:
3820-67-5
Molecular Weight:
372.80
UNSPSC Code:
41116107
PubChem Substance ID:
329799956
EC Number:
223-315-7
MDL number:
MFCD00079326

Key Documents

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InChI key

GWOFUCIGLDBNKM-UHFFFAOYSA-N

InChI

1S/C19H17ClN2O4/c20-12-5-6-14-17(7-8-21-18(14)9-12)22-16-4-2-1-3-15(16)19(25)26-11-13(24)10-23/h1-9,13,23-24H,10-11H2,(H,21,22)

SMILES string

OCC(O)COC(=O)c1ccccc1Nc2ccnc3cc(Cl)ccc23

grade

analytical standard

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

Gene Information

human ... PTGS1(5742), PTGS2(5743)

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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C Moesch et al.
European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies, 31(5), 329-333 (1993-05-01)
Glaphenine is an analgesic drug derived from anthranilic acid. We report the analytical procedures for stone analysis in three cases of common bile duct stones containing glaphenic acid, which developed in arthrosic patients treated for 13.7 +/- 5 years with
Renaud Robert et al.
Molecular pharmacology, 77(6), 922-930 (2010-03-05)
Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator (CFTR) gene, which encodes a cAMP-activated anion channel expressed in epithelial cells. The most common mutation Delta Phe508 leads to protein misfolding, retention by the endoplasmic reticulum
Bo Wen et al.
Drug metabolism and disposition: the biological fate of chemicals, 39(9), 1511-1521 (2011-06-02)
Glafenine (Privadol; 2,3-dihydroxypropyl 2-[(7-chloro-4-quinolinyl) amino]benzoate) is a non-narcotic analgesic agent widely used for the treatment of pains of various origins. Severe liver toxicity and a high incidence of anaphylaxis were reported in patients treated with glafenine, eventually leading to its
Mariusz Swiader et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 12(4), 311-319 (2002-07-20)
It was previously documented that calcium (Ca(2+)) channel inhibitors intensified the protective effects of conventional antiepileptics against electroconvulsions in mice. The aim of this study was to evaluate the effects of Ca(2+) channel inhibitors (nifedipine, nicardipine and flunarizine) on the
Claudia Müller et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 773(1), 47-52 (2002-05-17)
Ion suppression effects during electrospray-ionsation mass spectrometry (ESI-MS) caused by different sample preparation procedures for serum were investigated. This topic is of importance for systematic toxicological analysis for which LC-ESI-MS has been developed with transport-region collision-induced dissociation (ECI-CID) and mass
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