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Merck
CN

H2882

Hydrocortisone 21-hemisuccinate

analytical standard

Synonym(s):

11β,17α,21-Trihydroxy-4-pregnene-3,20-dione 21-hemisuccinate, Cortisol 21-hemisuccinate

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About This Item

Empirical Formula (Hill Notation):
C25H34O8
CAS Number:
2203-97-6
Molecular Weight:
462.53
NACRES:
NA.24
PubChem Substance ID:
329815187
UNSPSC Code:
41116107
EC Number:
218-612-3
MDL number:
MFCD00046256

Key Documents

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InChI key

VWQWXZAWFPZJDA-CGVGKPPMSA-N

InChI

1S/C25H34O8/c1-23-9-7-15(26)11-14(23)3-4-16-17-8-10-25(32,24(17,2)12-18(27)22(16)23)19(28)13-33-21(31)6-5-20(29)30/h11,16-18,22,27,32H,3-10,12-13H2,1-2H3,(H,29,30)/t16-,17-,18-,22+,23-,24-,25-/m0/s1

SMILES string

C[C@]12CCC(=O)C=C1CC[C@H]3[C@@H]4CC[C@](O)(C(=O)COC(=O)CCC(O)=O)[C@@]4(C)C[C@H](O)[C@H]23

grade

analytical standard

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

storage temp.

−20°C

Quality Level

200

Gene Information

human ... NR3C1(2908)

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360D

Hazard Classifications

Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

涉药品监管产品
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Certificates of Analysis (COA)

Lot/Batch Number
0000324561
0000324561
SLCJ5828
SLCC4599
SLBX2928

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Xiaohong Liu et al.
General and comparative endocrinology, 275, 65-72 (2019-02-16)
The pituitary is a central organ of the neuro-endocrine system in fish that plays critical roles in various physiological processes, including stress response and behavior. Although it is known that pituitary hormones can have a direct or indirect influence stimulating
Takahiro Michiba et al.
Auris, nasus, larynx, 40(2), 162-166 (2012-07-31)
Some patients with sudden sensorineural hearing loss (SSNHL) are frustrated by residual tinnitus even after accomplishment of the treatment for SSNHL. In the present prospective study, we examined patients' backgrounds of sex, laterality and age together with changes in hearing
Lars Hållström et al.
Critical care medicine, 36(11), 3043-3047 (2008-10-01)
Inhaled nitric oxide and glucocorticoids as a combination therapy may attenuate endotoxin-induced inflammatory responses in humans as indicated by levels of cytokines and clinical signs. Since other authors have shown that combined inhaled nitric oxide and steroids improved the histologic
Brian H Cuthbertson et al.
Intensive care medicine, 35(11), 1868-1876 (2009-08-05)
Use of etomidate in the critically ill is controversial due to its links with an inadequate response to corticotropin and potential for excess mortality. In a septic shock population, we tested the hypotheses that etomidate administration induces more non-responders to
Andrew J Semark et al.
Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine, 15(1), 63-66 (2013-02-26)
Bolus dose concentrations of hydrocortisone (50mg/mL) are reported to be incompatible with midazolam and ciprofloxacin in Y-site mixing studies. We evaluated the physical and chemical compatibility of low concentrations of hydrocortisone sodium succinate (1 mg/ mL) with midazolam (1 mg/mL
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