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H4759

Hydrochlorothiazide

crystalline

Synonym(s):

6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, 6-Chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide

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About This Item

Empirical Formula (Hill Notation):
C7H8ClN3O4S2
CAS Number:
58-93-5
Molecular Weight:
297.74
NACRES:
NA.77
PubChem Substance ID:
24277806
UNSPSC Code:
12352125
EC Number:
200-403-3
MDL number:
MFCD00051765
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form

crystalline

Quality Level

200

SMILES string

NS(=O)(=O)c1cc2c(NCNS2(=O)=O)cc1Cl

InChI

1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13)

InChI key

JZUFKLXOESDKRF-UHFFFAOYSA-N

Gene Information

human ... ALB(213), CA1(759), CA11(770), CA12(771), CA13(377677), CA14(23632), CA2(760), CA3(761), CA4(762), CA5A(763), CA6(765), CA7(766), CA8(767), CA9(768), SLC12A3(6559)

Biochem/physiol Actions

Carbonic anhydrase inhibitor

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pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H351

Hazard Classifications

Carc. 2

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

监管及禁止进口产品

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Certificates of Analysis (COA)

Lot/Batch Number
BCBL6365
BCBL6365V
SLBF4420V
090M1905V
090M1905

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A Dornhorst et al.
Lancet (London, England), 1(8421), 123-126 (1985-01-19)
14 hypertensive men with type II diabetes sequentially received, in random order, hydrochlorothiazide 50 mg twice a day, propranolol 80 mg twice a day, and both drugs in combination. The 3-week treatment periods were separated by a 1-week washout period.
Irfan A Dhalla et al.
Annals of internal medicine, 158(6), 447-455 (2013-04-05)
Some evidence suggests that chlorthalidone may be superior to hydrochlorothiazide for the treatment of hypertension. To compare the effectiveness and safety of chlorthalidone and hydrochlorothiazide in older adults. Propensity score-matched observational cohort study with up to 5 years of follow-up.
Franz H Messerli et al.
The American journal of medicine, 124(10), 896-899 (2011-10-04)
Hydrochlorothiazide (HCTZ) has become by far the most commonly prescribed antihypertensive drug in the US. In 2008, 47.8 million prescriptions were written for HCTZ alone and 87.1 million prescriptions for HCTZ combinations. However, there is no evidence that HCTZ in
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Global Trade Item Number

SKUGTIN
H4759-5G04061835545537
H4759-25G04061833796221
H4759-100G04061833796214