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Sigma-Aldrich

L-Histidine

ReagentPlus®, ≥99% (TLC)

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Synonym(s):
(S)-2-Amino-3-(4-imidazolyl)propionic acid, NSC 137773
Empirical Formula (Hill Notation):
C6H9N3O2
CAS Number:
71-00-1
Molecular Weight:
155.15
Beilstein:
84088
EC Number:
200-745-3
MDL number:
MFCD00064315
eCl@ss:
32160406
PubChem Substance ID:
24895816
NACRES:
NA.26

Quality Level

200

product line

ReagentPlus®

Assay

≥99% (TLC)

form

powder

color

white to off-white

mp

282 °C (dec.) (lit.)

solubility

0.5 M HCl: 50 mg/mL

application(s)

cell analysis

SMILES string

N[C@@H](Cc1c[nH]cn1)C(O)=O

InChI

1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1

InChI key

HNDVDQJCIGZPNO-YFKPBYRVSA-N

Gene Information

human ... CA1(759) , CA2(760)

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Application

L-histidine has been used for the selection of transformed cells. It has also been used to study its effects on the formation of verteporfin cross-linked oligomers in cellular homogenates.

Biochem/physiol Actions

L-Histidine is an essential amino acid. It binds to metal ions and may aid in the transport of copper. Histidine is widely present at the active sites of enzymes. It also has a role in binding of heme groups, macromolecules and phosphate groups in the binding sites of proteins.
Precursor of histamine by action of histidine decarboxylase.

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Catherine Collin, Masaru Minami, Hasan Parvez, Hideya Saito, Simone Parvez, Qureshi, Claude Reiss
Advances in Neurochemistry (2005)
Verteporfin-induced formation of protein cross-linked oligomers and high molecular weight complexes is mediated by light and leads to cell toxicity
Eleni K
Scientific Reports (2017)
Roger L. Lundblad
Chemical Reagents for Protein Modification (2014)
Markerless Gene Editing in the Hyperthermophilic Archaeon Thermococcus kodakarensis
Alexandra m
Bio-protocol (2017)
Kakulavarapu V Rama Rao et al.
The American journal of pathology, 176(3), 1400-1408 (2010-01-16)
Brain edema and the associated increase in intracranial pressure are potentially lethal complications of acute liver failure (ALF). Astrocyte swelling (cytotoxic edema) represents a significant component of the brain edema in ALF, and elevated blood and brain ammonia levels have
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