Skip to Content
Merck
CN

I1762

Isoxicam

analytical standard

Synonym(s):

4-Hydroxy-2-methyl-N-5-methyl-3-isoxolyl-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide

Sign In to View Organizational & Contract Pricing

Select a Size

About This Item

Empirical Formula (Hill Notation):
C14H13N3O5S
CAS Number:
34552-84-6
Molecular Weight:
335.34
EC Number:
252-084-5
MDL number:
MFCD00079374
UNSPSC Code:
41116107
PubChem Substance ID:
329815356
NACRES:
NA.24

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

grade

analytical standard

Quality Level

200

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

CN1C(C(=O)Nc2cc(C)on2)=C(O)c3ccccc3S1(=O)=O

InChI

1S/C14H13N3O5S/c1-8-7-11(16-22-8)15-14(19)12-13(18)9-5-3-4-6-10(9)23(20,21)17(12)2/h3-7,18H,1-2H3,(H,15,16,19)

InChI key

YYUAYBYLJSNDCX-UHFFFAOYSA-N

Gene Information

human ... PTGS1(5742), PTGS2(5743)

Related Categories

General description

Isoxicam is a long acting anti-inflammatory agent belonging to the oxicam group, and helps in relieving the symptoms of degenerative joint disease and rheumatoid arthritis. Its mode of action involves the ability to inhibit prostaglandin synthesis by suppressing the formation of cyclooxygenase and subsequent prostaglandin.

Application

Isoxicam may be used as an internal standard for the quantification of meloxicam in pharmaceutical preparations and as an analytical reference standard for the quantification of the analyte in biological samples using different analytical techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

E M Grace et al.
Current medical research and opinion, 10(9), 580-591 (1987-01-01)
Nineteen patients, aged 60 years and over, with rheumatoid arthritis participated in a clinical trial to investigate the pharmacokinetics of isoxicam (a new non-steroidal anti-inflammatory drug) in this age group. The purpose of the study was to determine if the
Oxicams: metabolic disposition in man and animals.
T F Woolf et al.
Drug metabolism reviews, 21(2), 255-276 (1989-01-01)
M Tariq
Research communications in chemical pathology and pharmacology, 60(1), 19-25 (1988-04-01)
The protective effect of some novel nonsteroidal anti-inflammatory agents has been studied on the endotoxin (lipopolysaccharide B) shock induced mortality in mice and biochemical changes in rats. All the three compounds included in this report, namely isoxicam, fentiazac and ketoprofen
W Kullich et al.
Zeitschrift fur Rheumatologie, 49(2), 77-81 (1990-03-01)
The influence of the oxicams, a special group of non-steroidal anti-inflammatory drugs, to the sister chromatid exchange (SCE) was determined on human lymphocytes in vitro and in vivo. The analysis of SCE is a sensitive parameter indicating chromosomal damage. The
H Fenner
Scandinavian journal of rheumatology. Supplement, 65, 97-101 (1987-01-01)
The chronicity of the inflammatory process requires persistent tissue concentrations of non-steroidal anti-inflammatory drugs (NSAIDs), best achieved by using a drug with a long half-life as a once-daily regimen. The oxicams proved to be one of the most promising classes
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service